지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 342 - 349 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Compared with warfarin, novel oral anticoagulants (NOACs) are convenient to use, although they require a blanking periodimmediately before radiofrequency catheter ablation for atrial fibrillation (AF). We compared NOACs and uninterrupted warfarinin the peri-procedural period of AF ablation.
Materials and Methods: We compared 141 patients treated with peri-procedural NOACs (72% men; 58±11 years old; 71% with paroxysmal AF) and 281 age-, sex-, AF type-, and history of stroke-matched patients treated with uninterrupted warfarin. NOACs were stopped 24 hours before the procedure and restarted on the same procedure day after hemostasis was achieved.
Results: We found no difference in the CHA2DS2-VASc (p=0.376) and HAS-BLED scores (p=0.175) between the groups. The pre-procedural anticoagulation duration was significantly shorter in the NOAC group (76.3±110.7 days) than in the warfarin group (274.7±582.7 days, p<0.001). The intra-procedural total heparin requirement was higher (p<0.001), although mean activated clottingtime was shorter (350.0±25.0 s vs. 367.4±42.9 s, p<0.001), in the NOAC group than in the warfarin group. There was no significantdifference in thromboembolic events (1.4% vs. 0%, p=0.111) or major bleeding (1.4% vs. 3.9%, p=0.235) between the NOAC and warfarin groups. Minor stroke occurred in two cases within 10 hours of the procedure (underlying CHA2DS2-VASc scores 0 and 1) in the NOAC group.
Conclusion: Pre-procedural anticoagulation duration was shorter and intra-procedural heparin requirement was higher with NOAC than with uninterrupted warfarin during AF ablation. Although the peri-procedural thromboembolism and bleeding incidencesdid not differ, minor stroke occurred in two cases in the NOAC group.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Haïssaguerre M / 1998 / Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins / N Engl J Med 339:659~666
January CT / 2014 / 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society / J Am Coll Cardiol 64:e1~e76
Spragg DD / 2008 / Complications of catheter ablation for atrial fibrillation: incidence and predictors / J Cardiovasc Electrophysiol 19:627~631
Cappato R / 2009 / Prevalence and causes of fatal outcome in catheter ablation of atrial fibrillation / J Am Coll Cardiol 53:1798~1803
Page SP / 2014 / Periprocedural stroke risk in patients undergoing catheter ablation for atrial fibrillation on uninterrupted warfarin / J Cardiovasc Electrophysiol 25:585~590
January CT / 2014 / 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society / J Am Coll Cardiol 64:e1~e76
Spragg DD / 2008 / Complications of catheter ablation for atrial fibrillation: incidence and predictors / J Cardiovasc Electrophysiol 19:627~631
Cappato R / 2009 / Prevalence and causes of fatal outcome in catheter ablation of atrial fibrillation / J Am Coll Cardiol 53:1798~1803
Page SP / 2014 / Periprocedural stroke risk in patients undergoing catheter ablation for atrial fibrillation on uninterrupted warfarin / J Cardiovasc Electrophysiol 25:585~590
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