지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,395 - 1,403 (9page)
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초록· 키워드
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Purpose: The objective of this study was to investigate clinical and laboratory parameters that could predict which patients could maintain adequate glycemic control after switching from initial insulin therapy to oral hypoglycemic agents (OHAs) among patients with type 2 diabetes (T2D).
Materials and Methods: We recruited 275 patients with T2D who had been registered in 3 cohorts of initiated insulin therapy and followed up for 33 months. The participants were divided into 2 groups according to whether they switched from insulin to OHAs (Group I) or not (Group II), and Group I was further classified into 2 sub-groups: maintenance on OHAs (Group IA) or resumption of insulin (Group IB).
Results: Of 275 patients with insulin initiation, 63% switched to OHAs (Group I) and 37% continued insulin (Group II). Of these, 44% were in Group IA and 19% in Group IB. The lowest tertile of baseline postprandial C-peptide-to-glucose ratio (PCGR), higher insulin dose at switching to OHAs, and higher HbA1c level at 6 months after switching to OHAs were all associated with OHA failure(Group IB; p=0.001, 0.046, and 0.014, respectively). The lowest tertile of PCGR was associated with ultimate use of insulin (Group IB and Group II; p=0.029).
Conclusion: Higher baseline level of PCGR and lower HbA1c levels at 6 months after switching to OHAs may be strong predictors for the successful maintenance of OHAs after switching from insulin therapy in Korean patients with T2D.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
DeFronzo RA / 1988 / Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM / Diabetes 37:667~687
Kahn SE / 2003 / The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes / Diabetologia 46:3~19
김유정 / 2015 / Effect of Socio-Economic Status on the Prevalence of Diabetes / Yonsei Medical Journal 56(3):641~647
Weng J / 2008 / Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial / Lancet 371:1753~1760
Kramer CK / 2013 / Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis / Lancet Diabetes Endocrinol 1:28~34
Kahn SE / 2003 / The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes / Diabetologia 46:3~19
김유정 / 2015 / Effect of Socio-Economic Status on the Prevalence of Diabetes / Yonsei Medical Journal 56(3):641~647
Weng J / 2008 / Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial / Lancet 371:1753~1760
Kramer CK / 2013 / Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis / Lancet Diabetes Endocrinol 1:28~34
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