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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 382 - 389 (8page)
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초록· 키워드
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Background: Conflicting results have been reported on the efficacy of insulin degludec/insulin aspart (IDegAsp) compared to basalinsulin in type 2 diabetes. We investigated the effects of changing basal insulin to IDegAsp on glycemic control and sought to identify factors related to those effects. Methods: In this retrospective study of patients from three referral hospitals, patients with type 2 diabetes using basal insulin withhemoglobin A1c (HbA1c) levels less than 11.0% were enrolled. Basal insulin was replaced with IDegAsp, and data were analyzedfrom 3 months before to 3 months after the replacement. Results: Eighty patients were recruited (52.5% male; mean age, 67.0±9.8 years; mean duration of diabetes, 18.9±8.5 years; meanHbA1c, 8.7%±1.0%). HbA1c levels increased during 3 months of basal insulin use, but significantly decreased after changing toIDegAsp (8.28%±1.10%, P=0.0001). The reduction was significant at 6 months in 35 patients whose longer-term data were available. Patients with a measured fasting plasma glucose (m-FPG) lower than their predicted FPG (p-FPG) by regression from HbA1cshowed a significant HbA1c reduction caused by the change to IDegAsp, even without a significantly increased insulin dose. However, patients whose m-FPG was higher than their p-FPG did not experience a significant HbA1c reduction, despite a significantlyincreased insulin dose. Furthermore, the HbA1c reduction caused by IDegAsp was significant in patients with low fasting C-peptidelevels and high insulin doses. Conclusion: We observed a significant glucose-lowering effect by replacing basal insulin with IDegAsp, especially in patients witha lower m-FPG than p-FPG.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
하경화 / 2018 / Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index / Diabetes and Metabolism Journal 42(2):137~146
Rudenski AS / 1988 / Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment / Diabet Med 5:36~41
이병완 / 2017 / Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017 / Diabetes and Metabolism Journal 41(5):367~373
Lamos EM / 2015 / Pharmacokinetics and pharmacodynamics of insulin glargine-insulin glulisine basal-bolus and twice-daily premixed analog insulin in type 1 diabetes mellitus patients during three standardized meals / J Clin Transl Endocrinol 3:14~20
Sarbacker GB / 2016 / Adherence to insulin therapy / Diabetes Spectr 29:166~170
Rudenski AS / 1988 / Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment / Diabet Med 5:36~41
이병완 / 2017 / Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017 / Diabetes and Metabolism Journal 41(5):367~373
Lamos EM / 2015 / Pharmacokinetics and pharmacodynamics of insulin glargine-insulin glulisine basal-bolus and twice-daily premixed analog insulin in type 1 diabetes mellitus patients during three standardized meals / J Clin Transl Endocrinol 3:14~20
Sarbacker GB / 2016 / Adherence to insulin therapy / Diabetes Spectr 29:166~170
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