지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 279 - 286 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternalserotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role in mothers remains unclear. We evaluated the role of serotonin in ventricular repolarization in mice hearts via 5Htr3 receptor (Htr3a) and investigated the mechanism of QT-prolongation during pregnancy. Materials and Methods: We measured current amplitudes and the expression levels of voltage-gated K+ (Kv) channels in freshly-isolated left ventricular myocytes from wild-type non-pregnant (WT-NP), late-pregnant (WT-LP), and non-pregnant Htr3a homozygousknockout mice (Htr3a-/--NP). Results: During pregnancy, serotonin and tryptophan hydroxylase 1, a rate-limiting enzyme for the synthesis of serotonin, were markedly increased in hearts and serum. Serotonin increased Kv current densities concomitant with the shortening of the QT intervalin WT-NP mice, but not in WT-LP and Htr3a-/--NP mice. Ondansetron, an Htr3 antagonist, decreased Kv currents in WT-LP mice, but not in WT-NP mice. Kv4.3 directly interacted with Htr3a, and this binding was facilitated by serotonin. Serotonin increasedthe trafficking of Kv4.3 channels to the cellular membrane in WT-NP. Conclusion: Serotonin increases repolarizing currents by augmenting Kv currents. Elevated serotonin levels during pregnancy counterbalance pregnancy-related QT prolongation by facilitating Htr3-mediated Kv currents.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Pham TV / 2002 / Sex, hormones, and repolarization / Cardiovasc Res 53:740~751
Odening KE / 2012 / Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective / Heart Rhythm 9:823~832
Sauer AJ / 2007 / Long QT syndrome in adults / J Am Coll Cardiol 49:329~337
Eghbali M / 2005 / Molecular and functional signature of heart hypertrophy during pregnancy / Circ Res 96:1208~1216
Fiorica-Howells E / 2000 / Serotonin and the 5-HT(2B) receptor in the development of enteric neurons / J Neurosci 20:294~305
Odening KE / 2012 / Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective / Heart Rhythm 9:823~832
Sauer AJ / 2007 / Long QT syndrome in adults / J Am Coll Cardiol 49:329~337
Eghbali M / 2005 / Molecular and functional signature of heart hypertrophy during pregnancy / Circ Res 96:1208~1216
Fiorica-Howells E / 2000 / Serotonin and the 5-HT(2B) receptor in the development of enteric neurons / J Neurosci 20:294~305
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ondansetron Inhibits Voltage-Gated K+ Current of Ventricular Myocytes from Pregnant Mouse
International Journal of Arrhythmia
2017 .06
-
Associations between Serotonergic Genes and Escitalopram Treatment Responses in Patients with Depressive Disorder and Acute Coronary Syndrome: The EsDEPACS Study
PSYCHIATRY INVESTIGATION
2016 .01
-
Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety
Annals of Dermatology
2019 .01
-
Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Regulation of Systemic Energy Homeostasis by Peripheral Serotonin
Journal of mucopolysaccharidosis and rare disease
2016 .01
-
Investigating the Role of Serotonin Levels in Cognitive Impairments Associated with Long COVID-19
전남의대학술지
2024 .09
-
Factors associated with Hypertensive Retinopathy among People with Hypertension: A Systematic Review
지역사회간호학회지
2025 .03
-
Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2020 .01
-
Association of the Serotonin Receptor 3E Gene as a Functional Variant in the MicroRNA-510 Target Site with Diarrhea Predominant Irritable Bowel Syndrome in Chinese Women
Journal of Neurogastroenterology and Motility (JNM)
2016 .01
-
A case of postoperative serotonin syndrome following the administration of fentanyl, palonosetron, and meperidine -A case report-
Anesthesia and Pain Medicine
2015 .01
-
Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review
대한류마티스학회지
2016 .01
-
Effect of manganese and lead exposure on the expression of serotonin receptors in the stariatum of C57BL/6 mice
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Platelet Serotonin Concentration Is Associated with Illness Duration in Schizophrenia and Chronological Age in Depression
PSYCHIATRY INVESTIGATION
2020 .01
-
Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
Clinical Psychopharmacology and Neuroscience
2023 .05
-
Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
The Korean Journal of Physiology & Pharmacology
2017 .07
-
Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel
The Korean Journal of Physiology & Pharmacology
2018 .01
-
지역사회 거주 노인의 만성질환 수, 수면의 질 및 세로토닌 농도가 우울에 미치는 영향
지역사회간호학회지
2020 .12
-
Famotidine-induced reversal of meperidine-related serotonin syndrome -a case report-
Korean Journal of Anesthesiology
2017 .01
-
Inhibitory effects of the atypical antipsychotic, clozapine, on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
The Korean Journal of Physiology & Pharmacology
2022 .07
-
Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance
Diabetes and Metabolism Journal
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0