지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 287 - 291 (5page)
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초록· 키워드
오류제보하기
Prospective observational cohort study was performed to evaluate predictors for responsiveness to corticosteroid treatment in patients with acute respiratory distresssyndrome (ARDS). Over the study period, a total of 20 patients (male 70%, median age 69) with ARDS were treated with corticosteroid within 72 h after intubation.
The median lung injury score (LIS) and partial pressure of arterial oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratios (PF ratios) were 3.0 (interquartile range, 2.7‒3.0) and 146.6 (119.9‒179.4), respectively. The median levels of triggeringreceptor expressed on myeloid cells (TREM-1) and procollagen peptide type III in bronchoalveolar lavage (BAL) fluid were 349.3 (225.6‒634.9) pg/mL and 19.6 (11.7‒39.7) pg/mL, respectively. After 7 days of corticosteroid treatment, 10 (50%) patients showed response to the treatment (successful extubation in 7 and 1-point or more reduction in LIS in 3). Compared to non-responders, respondershad higher initial PF ratios (170.5 vs. 127.2, p=0.023), lower level of TREM-1 in BAL fluid (313.6 pg/mL vs. 520.5 pg/mL, p=0.029), and greater reduction in LIS at 3 days (-1 vs. 0, p<0.001). In conclusion, PF ratios and TREM-1 level in BAL fluid at baseline, and reduction in LIS at day 3 after the treatment were associatedwith the response to prolonged corticosteroid treatment (ClinicalTrials.gov Identifier: NCT01093287).
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
ARDS Definition Task Force / 2012 / Acute respiratory distress syndrome: the Berlin Definition / JAMA 307 : 2526 ~ 2533
Annane D / 2006 / Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome / Crit Care Med 34 : 22 ~ 30
Bernard GR / 1987 / High-dose corticosteroids in patients with the adult respiratory distress syndrome / N Engl J Med 317 : 1565 ~ 1570
Bernard GR / 1994 / The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination / Am J Respir Crit Care Me
Gibot S / 2004 / Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia / N Engl J Med 350 : 451 ~ 458
Annane D / 2006 / Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome / Crit Care Med 34 : 22 ~ 30
Bernard GR / 1987 / High-dose corticosteroids in patients with the adult respiratory distress syndrome / N Engl J Med 317 : 1565 ~ 1570
Bernard GR / 1994 / The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination / Am J Respir Crit Care Me
Gibot S / 2004 / Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia / N Engl J Med 350 : 451 ~ 458
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