지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 203 - 208 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Pulmonary surfactant (PS) replacement has been the gold standard therapy for neonatal respiratory distress syndrome; however, almost all commercial PSs contain animal proteins. We prepared a synthetic PS by using a human surfactant protein (SP) analog and evaluated its in vitro properties.
Materials and Methods: A peptide sequence (CPVHLKRLLLLLLLLLLLLLLLL) of human SP-C was chosen to develop the peptideanalog (SPa-C). The new synthetic SP-C PS (sSP-C PS) was synthesized from SPa-C, dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and palmitic acid. Physical properties of the sSP-C PS were evaluated by measuring the maximum and minimumsurface tensions (STs), surfactant spreading, and adsorption rate. In addition, we recorded an ST-area diagram. The data obtained on sSP-C PS were subsequently compared with those of purified natural bovine surfactant (PNBS), and the commercial product, Surfacten®.
Results: The sSP-C PS and Surfacten® were found to have maximum ST values of 32–33 mN/m, whereas that of PNBS was much lower at 19 mN/m. The minimum ST values of all three products were less than 10 mN/m. The values that were measured for the equilibrium ST of rapidly spreading sSP-C PS, Surfacten®, and PNBS were 27, 27, and 24 mN/m, respectively. The surface adsorptionswere found to be the same for all three PSs (20 mN/m). ST-area diagrams of sSP-C PS and Surfacten® revealed similar properties.
Conclusion: In an in vitro experiment, the physical properties exhibited by sSP-C PS were similar to those of Surfacten®. Further study is required to evaluate the in vivo efficacy.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Almlen A / 2010 / Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits / Neonatology 98 : 91 ~
Bae CW / 1991 / Purification of bovine lung natural surfactant and assessment of surface physical properties / J Korean Med Assoc 34 : 534 ~ 544
Bae CW / 1993 / Surfactant replacement therapy in neonates with respiratory distress syndrome: a collective evaluation of trials from 16 hospitals / J Korean Pediatr Soc 36 :
Bae CW / 1997 / Surfactant replacement therapy in RDS: a collaborative study of multi-center trials in Korea / J Korean Soc Neonatol 4 : 124 ~ 135
Davis AJ / 1998 / Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant / Am J Respir Crit Care Med 157 : 553 ~ 559
Bae CW / 1991 / Purification of bovine lung natural surfactant and assessment of surface physical properties / J Korean Med Assoc 34 : 534 ~ 544
Bae CW / 1993 / Surfactant replacement therapy in neonates with respiratory distress syndrome: a collective evaluation of trials from 16 hospitals / J Korean Pediatr Soc 36 :
Bae CW / 1997 / Surfactant replacement therapy in RDS: a collaborative study of multi-center trials in Korea / J Korean Soc Neonatol 4 : 124 ~ 135
Davis AJ / 1998 / Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant / Am J Respir Crit Care Med 157 : 553 ~ 559
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