지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Pulmonary surfactant instillation is the treatment of choice in neonatal respiratory distress syndrome. The development of artificial surfactant has three decades of history. Animal-derived artificial surfactant is used in most countries and consists of 80% phospholipids and glycerol. 10% of the formulation is comprised of surfactant proteins, which have the critical role in surfactant function of lowering surface tension in the alveoli. Synthetic surfactants are made using synthetic peptide analogues as the surfactant protein counterparts. These are not the same as the human surfactant protein sequences; however, researchers are attempting to find the ideal synthetic peptide sequence for use in synthetic surfactants. Prophylactic and rescue surfactant therapy are two main therapeutic options. A recent recommendation emphasizes the importance of rescue therapy with continuous positive nasal airway pressure, rather than prophylactic use immediate after birth. This article briefly reviews the history and physiology of surfactant use, as well as clinical practice of surfactant and future studies.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Clements JA / 1957 / Surface tension of lung extracts / Proc Soc Exp Biol Med (Maywood) 95:170~172
Avery ME / 1959 / Surface properties in relation to atelec-tasis and hyaline membrane disease / AMA J Dis Child 97:517~523
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1:55~59
Robertson B / 1992 / A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborative European Multi-centre Study Group / Eur J Pediatr 151:372~376
Sweet DG / 2013 / European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal res-piratory distress syndrome in preterm infants : 2013 update / Neonatology 103:353~368
Avery ME / 1959 / Surface properties in relation to atelec-tasis and hyaline membrane disease / AMA J Dis Child 97:517~523
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1:55~59
Robertson B / 1992 / A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborative European Multi-centre Study Group / Eur J Pediatr 151:372~376
Sweet DG / 2013 / European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal res-piratory distress syndrome in preterm infants : 2013 update / Neonatology 103:353~368
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