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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 809 - 816 (8page)
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초록· 키워드
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Human respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infection, such as bronchiolitis, bronchitis, or pneumonia, in both infants and the elderly. Despite the global burden of diseases attributable to RSV infection, no clinically approved vaccine is available, and a humanized monoclonal antibody for prophylaxis is not readily affordable in developingcountries. There are several hurdles to the successful development of RSV vaccines: immune-vulnerable target populations such as premature infants, pregnant women, and immunocompromised people; safety concerns associated with vaccine-enhanced diseases; repeated infection; and waning memory. To develop successful strategies for the prevention of RSV infection, it is necessaryto understand the protective and pathologic roles of host immune responses to RSV infection. In this review, we will summarizethe positive and negative relationship between RSV infection and host immunity and discuss strategies for the development of the first successful RSV vaccine.
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참고문헌 (71)
참고문헌 신청
Hall CB / 1991 / Immunity to and frequency of reinfection with respiratory syncytial virus / J Infect Dis 163:693~698
Volling C / 2014 / Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study / BMC Infect Dis 14:665
Bhoj VG / 2008 / MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus / Proc Natl Acad Sci U S A 105:14046~14051
Kawai T / 2007 / TLR signaling / Semin Immunol 19:24~32
Rudd BD / 2006 / Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection / J Immunol 176:1937~1942
Volling C / 2014 / Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study / BMC Infect Dis 14:665
Bhoj VG / 2008 / MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus / Proc Natl Acad Sci U S A 105:14046~14051
Kawai T / 2007 / TLR signaling / Semin Immunol 19:24~32
Rudd BD / 2006 / Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection / J Immunol 176:1937~1942
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