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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
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Background: Respiratory syncytial virus (RSV) is a major pathogen causing respiratory tract infections in infants and young children. The aim of this study was to confirm the genetic evolution of RSV causing respiratory infections in children at Daejeon in Korea, through G gene analysis of RSV-A and RSV-B strains that were prevalent from 2017 to 2019. Methods: Pediatric patients admitted for lower respiratory tract infections at The Catholic University of Korea Daejeon St. Mary's Hospital in the 2017 and 2018/2019 RSV seasonal epidemics, who had RSV detected via multiplex polymerase chain reaction (PCR) were included. The nucleic acid containing RSV-RNA isolated from each of the patients' nasal discharge during standard multiplex PCR testing was stored. The G gene was sequenced and phylogenetic analysis was performed using MEGA X program and the genotype was confirmed. Results: A total of 155 specimens including 49 specimens from 2017 and 106 specimens from 2018-2019 were tested. The genotype was confirmed in 18 specimens (RSV-A:RSV-B = 4:14) from 2017 and 8 specimens (RSV-A:RSV-B = 7:1) from 2018/2019. In the phylogenetic analysis, all RSV-A type showed ON1 genotype and RSV-B showed BA9 genotype. Conclusion: RSV-B belonging to BA9 in 2017, and RSV-A belonging to ON1 genotype in 2018/2019 was the most prevalent circulating genotypes during the two RSV seasons in Daejeon, Korea.
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참고문헌 (31)
참고문헌 신청
Korea Centers for Disease Control and Prevention / 2020 / Pathogens and Vector Surveillance Weekly Report 2020.08.09 to 2020.08.22
Hall CB / 2013 / Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age / Pediatrics 132(2):e341~e348
Blount RE Jr / 1956 / Recovery of cytopathogenic agent from chimpanzees with coryza / Proc Soc Exp Biol Med 92(3):544~549
Crowe JE Jr / 2003 / Immunology of viral respiratory tract infection in infancy / Paediatr Respir Rev 4(2):112~119
Kim YJ / 2014 / Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene / Infect Genet Evol 26:103~112
Hall CB / 2013 / Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age / Pediatrics 132(2):e341~e348
Blount RE Jr / 1956 / Recovery of cytopathogenic agent from chimpanzees with coryza / Proc Soc Exp Biol Med 92(3):544~549
Crowe JE Jr / 2003 / Immunology of viral respiratory tract infection in infancy / Paediatr Respir Rev 4(2):112~119
Kim YJ / 2014 / Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene / Infect Genet Evol 26:103~112
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