지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,597 - 1,603 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy.
Materials and Methods: We measured amounts of urinary albumin excretion (UAE) after administrating ATRA to Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In order to understand the mechanism of action for ATRA, we administrated ATRA to examineits inhibitory action on the production of transforming growth factor-β1 (TGF-β1), protein kinase C (PKC), and reactive oxidative stress (ROS) in cultured rat mesangial cells (RMCs).
Results: After 16 weeks of treatment, UAE was lower in the ATRA-treated OLETF rats than in the non-treated OLETF rats (0.07± 0.03 mg/mgCr vs. 0.17±0.15 mg/mgCr, p<0.01). After incubation of RMCs in media containing 30 or 5 mM of glucose, treatment with ATRA showed time- and dose-dependent decreases in TGF-β1 levels and ROS. Moreover, ATRA treatment showed a dose-dependent decrease in PKC expression.
Conclusion: ATRA treatment suppressed UAE and TGF-β1 synthesis, which was mediated by significant reductions in PKC activity and ROS production. Our results suggest that ATRA has a potential therapeutic role for diabetic nephropathy.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Koya D / 2000 / Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes / FASEB J 14:439~447
Carter CA / 2004 / Therapeutic potential of natural compounds that regulate the activity of protein kinase C / Curr Med Chem 11:2883~2902
Kahl-Rainer P / 1994 / Retinoids inhibit protein kinase C-dependent transduction of 1,2-diglyceride signals in human colonic tumor cells / Nutr Cancer 21:157~168
Simonson MS / 1994 / Anti-AP-1 activity of all-trans retinoic acid in glomerular mesangial cells / Am J Physiol 267(5 Pt 2):F805~F815
Kaul N / 1996 / Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy / Mol Cell Biochem 160:283~288
Carter CA / 2004 / Therapeutic potential of natural compounds that regulate the activity of protein kinase C / Curr Med Chem 11:2883~2902
Kahl-Rainer P / 1994 / Retinoids inhibit protein kinase C-dependent transduction of 1,2-diglyceride signals in human colonic tumor cells / Nutr Cancer 21:157~168
Simonson MS / 1994 / Anti-AP-1 activity of all-trans retinoic acid in glomerular mesangial cells / Am J Physiol 267(5 Pt 2):F805~F815
Kaul N / 1996 / Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy / Mol Cell Biochem 160:283~288
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Decreased metabolic activity and death induction of retinoic acid and fenbendazole on HL-60 cells
예방수의학회지
2021 .12
-
All-trans Retinoic Acid Induces Expression and Secretion of Carboxypeptidase D in THP-1 Cells
대한의생명과학회지
2020 .12
-
외이도의 종물 형태로 나타난 급성 전골수성 백혈병의 골수 외 재발 1예
대한이비인후-두경부외과학회지
2016 .01
-
All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells
Yonsei Medical Journal
2020 .01
-
패혈증 환자에서 전골수구성 백혈병양 반응을 나타낸 1예
Laboratory Medicine Online
2019 .01
-
Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats
Journal of Ginseng Research
2020 .03
-
Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy
Yonsei Medical Journal
2016 .01
-
Effect of the Sodium-Glucose Cotransporter 2 Inhibitor, Dapagliflozin, on Genitourinary Infection in an Animal Model of Type 2 Diabetes
International Neurourology Journal
2020 .01
-
Repeated dose 28 days toxicity study of dongchunghacho in OLETF rats
한국실험동물학회 학술발표대회 논문집
2016 .08
-
PHA-Induced Peripheral Blood Cytogenetics and Molecular Anslysis : a Valid Diagnostic and Follow-up Modality For Acute Primyelocytic Leukemia Patients Treated With ATRA and/or Arsenic Tri-oxide
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats
Osteoporosis and Sarcopenia
2016 .01
-
Identification of proteins differentially expressed by retinoic acid in an ischemic cerebral cortex animal model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
The Korean Journal of Physiology & Pharmacology
2017 .07
-
Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy
Diabetes and Metabolism Journal
2017 .01
-
Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy
Diabetes and Metabolism Journal
2015 .01
-
Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats
Journal of Ginseng Research
2017 .10
-
Effect of edaravone in diabetes mellitus-induced nephropathy in rats
The Korean Journal of Physiology & Pharmacology
2016 .07
-
Involvement of Protein Kinase C-δ in Vascular Permeability in Acute Lung Injury
Immune Network
2015 .08
-
Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
Endocrinology and Metabolism
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0