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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 7 - 11 (5page)
이용수
초록· 키워드
오류제보하기
Objectives: Bee venom (BV) is a complex mixture ofproteins and contains proteins such as phospholipaseand melittin, which have an effect on blood clottingand blood clots. The mechanism of action of honey beevenom (HBV, Apis mellifera) on human plasma proteinsand its anti-thrombotic effect were studied. The purposeof this study was to investigate the anti-coagulationeffect of BV and its effects on blood coagulation andpurification.
Methods: Crude venom obtained from Apis melliferawas selected. The anti-coagulation factor of the crudevenom from this species was purified by using gel filtrationchromatography (sephadex G-50), and the molecularweights of the anti-coagulants in this venom estimatedby using sodium dodecyl sulfate-polyacrylamide gelelectrophoresis (SDS-PAGE). Blood samples were obtainedfrom 10 rabbits, and the prothrombin time (PT)and the partial thromboplastin time (PTT) tests wereconducted. The approximate lethal dose (LD) values ofBV were determined.
Results: Crude BV increased the blood clotting time.
For BV concentrations from 1 to 4 mg/mL, clotting wasnot observed even at more than 300 seconds, standard deviations (SDs) = ± 0.71; however, clotting was observedin the control group 13.8 s, SDs = ± 0.52. Thus,BV can be considered as containing anti-coagulationfactors. Crude BV is composed 4 protein bands withmolecular weights of 3, 15, 20 and 41 kilodalton (kDa),respectively. The LD50 of the crude BV was found to be177.8 μg/mouse.
Conclusion: BV contains anti-coagulation factors. Thefraction extracted from the Iranian bees contains proteinsthat are similar to anti-coagulation proteins, suchas phospholipase A2 (PLA2) and melittin, and that canincrease the blood clotting times in vitro.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abdu Al-Samie MA / 2012 / Studies on bee venom and its med-ical uses / IJOART 1 (2) : 1 ~ 15
Babaie M / 2013 / Isolation and partial purification of anti-coagulant fractions from the venom of the Iranian snake Echis carinatus / Acta Biochim Pol 60 (1) : 17 ~ 20
Edstrom A. Venomous / 1992 / Venomous and poisonous animals / Krieger Publishing Company : 210 ~ 220
Habermann
Habermann E / 1966 / Uber die struktur des toxischen bienengiftpeptids melittin und deren beziehung zur pharmakologischen wirkung / Naunyn Schmiedebergs Arch Pharmacol 253 (1
Babaie M / 2013 / Isolation and partial purification of anti-coagulant fractions from the venom of the Iranian snake Echis carinatus / Acta Biochim Pol 60 (1) : 17 ~ 20
Edstrom A. Venomous / 1992 / Venomous and poisonous animals / Krieger Publishing Company : 210 ~ 220
Habermann
Habermann E / 1966 / Uber die struktur des toxischen bienengiftpeptids melittin und deren beziehung zur pharmakologischen wirkung / Naunyn Schmiedebergs Arch Pharmacol 253 (1
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