지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 64 - 68 (5page)
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초록· 키워드
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Objective: Serum concentrations of transaminase, pyruvate kinase (PK), and lactate dehydrogenase (LDH) are considered biochemical indicators of Duchenne muscular dystrophy (DMD), but they can also detect hepatocellular injury.
This study was designed to develop mathematical models that predict serum concentrations of these hepatic marker enzymes in Korean patients with DMD, based on their age and serum concentrations of creatine kinase (CK) and CK MB isoenzyme (CKMB).
Method: Boys with genetically confirmed DMD were identified retrospectively; all were normal for hepatic viral markers or on abdominal ultrasonography. Serum concentrations of CK, CKMB, transaminase, PK, and LDH were measured, and statistical analyses were performed to determine whether transaminase, PK, and LDH levels were related to age and serum CK and CKMB levels.
Results: The study included a total of 134 patients with DMD. Serum transaminase, PK, and LDH levels were linearly related to patient age and serum CK and CKMB levels. A mathematical model was developed, in which patient age and serum CK and CKMB concentrations can predict mean transaminase, PK, and LDH concentrations.
Conclusion: This mathematical model may provide some reassurance to DMD patients with high serum concentrations of hepatic marker enzymes and prevent unnecessary procedures to exclude hepatic dysfunction.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Badalamente MA / 2000 / Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition / Muscle Nerve 23 : 106 ~ 111
De La Porte S / 1999 / Characteristics of skeletal muscle in mdx mutant mice / Int Rev Cytol 191 : 99 ~ 148
Hammerer-Lercher A / 2001 / Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy / Clin Chem 47 (3) : 451 ~ 458
Il-Young Jung / 2012 / The Correlation Analysis of Functional Factors and Age with Duchenne Muscular Dystrophy / Annals of Rehabilitation Medicine 36 (1) : 22 ~ 32
Mazurek S / 2005 / Pyruvate kinase type M2 and its role in tumor growth and spreading / Semin Cancer Biol 15 (4) : 300 ~ 308
De La Porte S / 1999 / Characteristics of skeletal muscle in mdx mutant mice / Int Rev Cytol 191 : 99 ~ 148
Hammerer-Lercher A / 2001 / Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy / Clin Chem 47 (3) : 451 ~ 458
Il-Young Jung / 2012 / The Correlation Analysis of Functional Factors and Age with Duchenne Muscular Dystrophy / Annals of Rehabilitation Medicine 36 (1) : 22 ~ 32
Mazurek S / 2005 / Pyruvate kinase type M2 and its role in tumor growth and spreading / Semin Cancer Biol 15 (4) : 300 ~ 308
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