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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. Methods: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed. Results: Of the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, patients of male sex (odds ratio [OR]=0.06, P<0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P<0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=-0.21, P=0.023). Conclusions: The prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.
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참고문헌 (24)
참고문헌 신청
/ 2001 / NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy / JAMA 285 : 785 ~ 795
Bolton CE / 2004 / Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 170 : 1286 ~ 1293
Ferguson GT / 2009 / Prevalence and progression of osteoporosis in patients with COPD:results from the TOwards a Revolution in COPD Health study / Chest 136 : 1456 ~ 1465
Franco CB / 2009 / Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D / Osteoporos Int 20 : 1881 ~ 1887
Gan WQ / 2004 / Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis / Thorax 59 : 574 ~ 580
Bolton CE / 2004 / Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 170 : 1286 ~ 1293
Ferguson GT / 2009 / Prevalence and progression of osteoporosis in patients with COPD:results from the TOwards a Revolution in COPD Health study / Chest 136 : 1456 ~ 1465
Franco CB / 2009 / Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D / Osteoporos Int 20 : 1881 ~ 1887
Gan WQ / 2004 / Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis / Thorax 59 : 574 ~ 580
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