지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis. COPD-associated osteoporosis is however extremely under-recognized, hence undertreated. Recent studies have suggested that both decreased bone mineral density (BMD) and impaired bone quality compromise bone strength causing fractures in COPD. In COPD patients, various general clinical risk factors for osteoporosis are present including smoking, older age, low body weight, and physical inactivity. In addition, disease-related risk factors such as decreased pulmonary function, inflammation, glucocorticoid use and vitamin D deficiency/insufficiency have been linked to the development of osteoporosis in COPD. Increased awareness of osteoporosis in COPD, especially that of high prevalence of vertebral fractures is called upon among general physicians as well as pulmonologists. Routine screening for osteoporosis and risk assessment of fractures will enable physicians to diagnose COPD patients with comorbid osteoporosis at an early stage.
Timely prevention of developing osteoporosis together with appropriate treatment of established osteoporosis may improve QOL and ADL of the COPD patients, preserve their lung function and eventually result in better prognosis in these patients.
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등록된 정보가 없습니다.
참고문헌 (100)
참고문헌 신청
Sarkar M / 2015 / Osteoporosis in chronic obstructive pulmonary disease / Clin Med Insights Circ Respir Pulm Med 9:5~21
Decramer M / 2012 / Chronic obstructive pulmonary disease / Lancet 379:1341~1351
Burgel PR / 2013 / Impact of comorbidities on COPD-specific health-related quality of life / Respir Med 107:233~241
Frei A / 2014 / Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease : the newly developed COMCOLD index / J Clin Epidemiol 67:904~911
Graat-Verboom L / 2009 / Current status of research on osteoporosis in COPD : a systematic review / Eur Respir J 34:209~218
Decramer M / 2012 / Chronic obstructive pulmonary disease / Lancet 379:1341~1351
Burgel PR / 2013 / Impact of comorbidities on COPD-specific health-related quality of life / Respir Med 107:233~241
Frei A / 2014 / Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease : the newly developed COMCOLD index / J Clin Epidemiol 67:904~911
Graat-Verboom L / 2009 / Current status of research on osteoporosis in COPD : a systematic review / Eur Respir J 34:209~218
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