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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 411 - 419 (9page)
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초록· 키워드
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Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dim ethyl-D-erythro-sphingosine (DMS), might lead to sustained ceramide accumulation in cells more efficiently, thereby sensitizing them to γ-radiation-induced cell death.
To delineate this problem, the clonogenic survival of Lewis lung carcinoma (LLC) cells was evaluated following exposure to radiation together with or without C2-ceramide, DMS, or both.
The treatment of ceramide/DMS synergistically decreased the survival of the irradiated cells compared with treatm ent with ceramide or DMS alone. Ceramide/DMS-treated cells displayed several apoptotic features after γ-irradiation, including increased sub G1 population, TUNEL-positive fraction, and poly-(ADP-ribose) polymerase (PARP) cleavage. We also observed ceramide/ DMS induced disruption of mitochondrial membrane potential (MMP) and activation of caspase- 9 and -3 in a radiation-dose-dependent manner.
Furthermore, pretreatment of LLC cells with ceramide/ DMS not only increased the protein expression level of Bax, but also decreased Bcl-2 after γ-irradiation. Taken together, the present study indicates that the radiosensitizing activity of ceramide/DMS on LLC cells most likely reflects the dominance of pro-apoptotic signals related to the mitochondria-dependent pathway.
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참고문헌 (28)
참고문헌 신청
/ / Changing views of cellularradiosensitivity : 299 ~ 311
/ 1996 / New members of the Bcl-2 family andtheir protein partners : 45 ~ 9
/ 1996 / Therole of c-Jun N-terminal kinase Duration of JNKactivation may determine cell death and proliferation : 31929 ~ 36
/ 1997 / Bcl-xL overexpression inhibitsprogression of molecular events leading to paclitaxel-inducedapoptosis of human acute myeloid leukemia HL-60 cells : 1109 ~ 15
/ 1997 / Cytochrome c and dATP-dependentformation of Apaf-1/caspase-9 complex initiates an apoptoticprotease cascade : 479 ~ 89
/ 1996 / New members of the Bcl-2 family andtheir protein partners : 45 ~ 9
/ 1996 / Therole of c-Jun N-terminal kinase Duration of JNKactivation may determine cell death and proliferation : 31929 ~ 36
/ 1997 / Bcl-xL overexpression inhibitsprogression of molecular events leading to paclitaxel-inducedapoptosis of human acute myeloid leukemia HL-60 cells : 1109 ~ 15
/ 1997 / Cytochrome c and dATP-dependentformation of Apaf-1/caspase-9 complex initiates an apoptoticprotease cascade : 479 ~ 89
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CERAMIDE-MEDIATED SIGNAL TRANSDUCTION AND c-jun GENE EXPRESSION DURING DIFFERENTIATION OP U-931 CELLS
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Introduction of p53-independent p21 during ceramide-mediated G1 arrest in SK-Hep 1 cell
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LC-MS/MS analysis of ceramide in Chronic kidney disease (CKD) model induced by adenine
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Ceramide and Sphingosine 1-Phosphate in Liver Diseases
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CERAMIDE-MEDIATED SIGMAL TRANSDUCTION AND c-jun GENE EXPRESSION BORING DIFFERENTIATION OF U-937 CELLS.
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Ceramide Synthase is Required for Lipid Raft Polarization and Filamentous Growth in Yeast
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Stearoyl-CoA desaturase induces lipogenic gene expression in prostate cancer cells and inhibits ceramide-induced cell death
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Expression Patterns of Ceramide Glucosyltransferase during Mice Postimplantation Embryogenesis
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