지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial infection plays a role in its pathogenesis. Bacteria secrete nanometer-sized extracellular vesicles (EVs), which may induce more immune dysfunction and inflammation than the bacteria themselves. We hypothesized that the microbiome of lung EVs might have distinct characteristics depending on the presence of COPD and smoking status. We analyzed and compared the microbiomes of 13 nonsmokers with normal spirometry, 13 smokers with normal spirometry (healthy smokers) and 13 patients with COPD by using 16S ribosomal RNA gene sequencing of surgical lung tissue and lung EVs. Subjects were matched for age and sex in all groups and for smoking levels in the COPD and healthy smoker groups. Each group included 12 men and 1 woman with the same mean age of 65.5 years. In all groups, EVs consistently showed more operational taxonomic units (OTUs) than lung tissue. In the healthy smoker and COPD groups, EVs had a higher Shannon index and a lower Simpson index than lung tissue and this trend was more prominent in the COPD group. Principal component analysis (PCA) showed clusters based on sample type rather than participants’ clinical characteristics. Stenotrophomonas, Propionibacterium and Alicyclobacillus were the most commonly found genera. Firmicutes were highly present in the EVs of the COPD group compared with other samples or groups. Our analysis of the lung microbiome revealed that the bacterial communities present in the EVs and in the COPD group possessed distinct characteristics with differences in the OTUs, diversity indexes and PCA clustering.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
[학술지(정기간
Burney PGJ / 2015 / Global and regional trends in COPD mortality, 1990?2010 / Eur Respir J 45 : 1239 ~ 1247
Camilli AE / 1987 / Longitudinal changes in forced expiratory volume in one second in adults. Effects of smoking and smoking cessation / Am Rev Respir Dis 135 : 794 ~ 799
Charlson ES / 2011 / Topographical continuity of bacterial populations in the healthy human respiratory tract / Am J Respir Crit Care Med 184 : 957 ~ 963
Charlson ES / 2012 / Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts / PLoS ONE 7 : e42786 ~
Burney PGJ / 2015 / Global and regional trends in COPD mortality, 1990?2010 / Eur Respir J 45 : 1239 ~ 1247
Camilli AE / 1987 / Longitudinal changes in forced expiratory volume in one second in adults. Effects of smoking and smoking cessation / Am Rev Respir Dis 135 : 794 ~ 799
Charlson ES / 2011 / Topographical continuity of bacterial populations in the healthy human respiratory tract / Am J Respir Crit Care Med 184 : 957 ~ 963
Charlson ES / 2012 / Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts / PLoS ONE 7 : e42786 ~
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Machine Learning Approaches to Select Best Features to Classify the COPD Data
한국정보통신학회 종합학술대회 논문집
2020 .10
-
Machine-learning algorithms for asthma, COPD, and lung cancer risk assessment using circulating microbial extracellular vesicle data and their application to assess dietary effects
Experimental and Molecular Medicine
2022 .09
-
의료사물인터넷 기반 모니터링 서비스를 활용한 만성폐쇄성폐질환 환자의 임상적 유효성 비교분석
보건의료생명과학논문지
2024 .07
-
MultiModal Learning을 활용한 COPD 환자의 병원 내 사망 예측
한국재활복지공학회 학술대회 논문집
2021 .11
-
만성폐쇄성폐질환자의 신체활동 관련 요인: 2013-2015 국민건강영양조사 자료 활용
보건정보통계학회지
2021 .01
-
미세먼지로 유발된 만성폐쇄성폐질환에서 호중구 세포외 덫의 역할
Journal of the Environment
2024 .12
-
워드 임베딩을 이용한 COPD와 암 관련 바이오마커의 상관관계 분석
한국어정보학회 학술대회
2017 .01
-
국외논문정보 - 만성 폐쇄성 폐질환(COPD) 중증도와 작업 생산도, 건강 관련 삶의 질, 의료자원 이용과의 관계
산업보건
2017 .01
-
창의공학 교육을 위한 LEGOⓇ MindstormsⓇ EV3 연구
전자공학회지
2016 .09
-
Strategies to Enhance Extracellular Vesicle Production
조직공학과 재생의학
2021 .01
-
The impact of bacteria-derived ultrafine dust particles on pulmonary diseases
Experimental and Molecular Medicine
2020 .01
-
Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
조직공학과 재생의학
2023 .04
-
Emerging role of extracellular vesicles in the respiratory system
Experimental and Molecular Medicine
2020 .01
-
A new horizon of precision medicine: combination of the microbiome and extracellular vesicles
Experimental and Molecular Medicine
2022 .04
-
Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities
조직공학과 재생의학
2024 .06
-
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Experimental and Molecular Medicine
2019 .01
-
구조분석 방법을 이용한 EV 구동시스템의 고장분석
한국자동차공학회 추계학술대회 및 전시회
2021 .11
-
미세먼지 매개 폐질환 연구를 위한 오가노이드 모델 활용
Journal of the Environment
2024 .06
-
Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers
Experimental and Molecular Medicine
2020 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0