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논문 기본 정보
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- 학술저널
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- 2017.1
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The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic modification in mammalian genomes, and its abnormalities are intimately coupled to various pathogenic processes including cancer development.
Enzymes of the Ten–eleven translocation (TET) family catalyze the stepwise oxidation of 5-methylcytosine in DNA to 5-hydroxymethylcytosine and further oxidation products. These oxidized 5-methylcytosine derivatives represent intermediates in the reversal of cytosine methylation, and also serve as stable epigenetic modifications that exert distinctive regulatory roles. It is becoming increasingly obvious that TET proteins and their catalytic products are key regulators of embryonic development, stem cell functions and lineage specification. Over the past several years, the function of TET proteins as a barrier between normal and malignant states has been extensively investigated. Dysregulation of TET protein expression or function is commonly observed in a wide range of cancers. Notably, TET loss-of-function is causally related to the onset and progression of hematologic malignancy in vivo. In this review, we focus on recent advances in the mechanistic understanding of DNA methylation–demethylation dynamics, and their potential regulatory functions in cellular differentiation and oncogenic transformation.
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참고문헌 (27)
참고문헌 신청
Andrews AJ / 2011 / Nucleosome structure(s) and stability: variations on a theme / Annu Rev Biophys 40 : 99 ~ 117
Arita K / 2008 / Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism / Nature 455 : 818 ~ 821
Avvakumov GV / 2008 / Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 / Nature 455 : 822 ~ 825
Borst P / 2008 / discovery, biosynthesis, and possible functions / Annu Rev Microbiol 62 : 235 ~ 251
Bostick M / 2007 / UHRF1plays a role in maintaining DNA methylation in mammalian cells / Science 317 : 1760 ~ 1764
Arita K / 2008 / Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism / Nature 455 : 818 ~ 821
Avvakumov GV / 2008 / Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 / Nature 455 : 822 ~ 825
Borst P / 2008 / discovery, biosynthesis, and possible functions / Annu Rev Microbiol 62 : 235 ~ 251
Bostick M / 2007 / UHRF1plays a role in maintaining DNA methylation in mammalian cells / Science 317 : 1760 ~ 1764
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Detecting DNA hydroxymethylation: exploring its role in genome regulation
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Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
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DNA methylation-based age prediction from various tissues and body fluids
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Forensic DNA methylation profiling from evidence material for investigative leads
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Vitamin C enhances the expression of IL17 in a Jmjd2−dependent manner
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Histone lysine demethylases in mammalian embryonic development
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Confirmation of no Causal Relationship between Genome-wide DNA Methylation and Transcriptome Changes after Gamma Irradiation
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Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
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Utilizing Deep Learning Model to Identify DNA N4-Methylcytosine Sites
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