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- 자료유형
- 학술저널
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- 2015.1
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Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of mesenchymalphenotypes of basal-type breast cancer cells remain obscure. Here, we report that KRAS is a critical regulator for the maintenance of mesenchymal features in basal-type breast cancer cells. KRAS is preferentially activated in basal-type breastcancer cells as compared with luminal type. By loss and gain of KRAS, we found that KRAS is necessary and sufficient for the maintenance of mesenchymal phenotypes and metastatic ability through SLUG expression. Taken together, this studydemonstrates that KRAS is a critical regulator for the metastatic behavior associated with mesenchymal features of breast cancer cells, implicating a novel therapeutic target for basal-type breast cancer.
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참고문헌 (24)
참고문헌 신청
Badve S / 2011 / Basal-like and triple-negative breast cancers : a critical review with an emphasis on the implications for pathologists and oncologists / Mod Pathol 24 : 15
Bailey CK / 2012 / High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG / J Biol Chem 287 : 194
Choi Y / 2013 / Epithelialmesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer / Hum Pathol 44 : 2581 ~ 2589
Crespo P / 2000 / Ras proteins in the control of the cell cycle and cell differentiation / Cell Mol Life Sci 57 : 1613 ~ 1636
Eckert LB / 2004 / Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis / Cancer Res 64 : 4585 ~ 4592
Bailey CK / 2012 / High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG / J Biol Chem 287 : 194
Choi Y / 2013 / Epithelialmesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer / Hum Pathol 44 : 2581 ~ 2589
Crespo P / 2000 / Ras proteins in the control of the cell cycle and cell differentiation / Cell Mol Life Sci 57 : 1613 ~ 1636
Eckert LB / 2004 / Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis / Cancer Res 64 : 4585 ~ 4592
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