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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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- 1 - 12 (12page)
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In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression isrestricted to hematopoietic cells, whereas H4 is ubiquitously expressed. H60-specific CD8 T-cell response has been known to be dominant in most cases of B6 anti-BALB.B allo-responses, except in the case of skin transplantation. To understand themechanism underlying the subdominance of H60 during allogeneic skin ransplantation, we investigated the dynamics of the H60-specific CD8 T cells in B6 mice transplanted with allogeneic BALB.B tail skin. Unexpectedly, longitudinal bioluminescence imaging and flow cytometric analyses revealed that H60-specific CD8 T cells were not always subdominant to H4-specific cells but instead showed a brief dominance before the H4 response became predominant. H60-specific CD8 T cells could expand in the draining lymph node and migrate to the BALB.B allografts, indicating their active participation in the anti-BALB.B alloresponse. Enhancing the frequencies of H60-reactive CD8 T cells prior to skin transplantation reversed the immune hierarchy between H60 and H4. Additionally, H60 became predominant when antigen presentation was limited to the direct pathway. However, when antigen presentation was restricted to the indirect pathway, the expansion of H60-specific CD8 T cells was limited, whereas H4-specific CD8 T cells expanded significantly, suggesting that the temporary immunodominance and eventual subdominance of H60 could be due to their reliance on the direct antigen presentation pathway. These results enhance our understanding of the immunodominance phenomenon following allogeneic tissue transplantation.
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참고문헌 (23)
참고문헌 신청
Anderson CC / 2001 / Immunity or tolerance : opposite outcomes of microchimerism from skin grafts / Nat Med 7 : 80 ~ 87
Celli S / 2011 / Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy / Nat Med 17 : 744 ~ 749
Choi EY / 2001 / Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo : the H60 histocompatibility antigen dominates over all others
Choi EY / 2002 / Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide / Immunity
Choi EY / 2002 / Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease / Blood 100 : 4259 ~ 4265
Celli S / 2011 / Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy / Nat Med 17 : 744 ~ 749
Choi EY / 2001 / Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo : the H60 histocompatibility antigen dominates over all others
Choi EY / 2002 / Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide / Immunity
Choi EY / 2002 / Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease / Blood 100 : 4259 ~ 4265
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