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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 261 - 270 (10page)
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초록· 키워드
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CD98, a disulfide-linked 125-kDa heterodimeric type I transmembrane glycoprotein, regulates β1 integrin- mediated cell adhesion. However, the molecular mech-anisms underlying CD98-mediated activation of β1 in-tegrin are presently unclear. In this study, the effects of CD98 signaling on the expression and clustering of β1 integrin were investigated. Activation of CD98 aug-mented surface expression of β1 integrin on MCF-7 cells. Cross-linking CD98 induced clustering of β1 integrins. Inhibition of phosphorylation of focal adhe-sion kimase (FAK) by PP2, an inhibitor of Src family kin-not surface expression and clustering of β1 integrin on MCF-7 cells. This result was confirmed by over-ex-pression of dominant negative forms of FAK. In addi-tion, phaloidin or cytochalasin D inhibited CD98-medi-ated induction of cell-ECM adhesion, but not surface expression and clustering of β1 integrins. The in-hibitory effects of PP2, cytochalasin D or phaloidin on CD98-stimulated cell adhesion were diminished by pretreatment of cells with Mn2+, which is shown to in-duce conformational change of integrins. These re-sults provide the first evidence that CD98 activation in-creases not only β1 integrin afinity but also its surface expression and clustering and the latter is independent of FAK/Src and cytoskeleton.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alon R / 2007 / Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells / Immunity 26 : 17 ~ 27
Bellone G / 1989 / Identification of a new epitope of the 4F2/44D7 molecular complex present on sarcolemma and isolated cardiac fibers / Eur J Immunol 19 : 1 ~ 8
Berditchevski F / 2001 / Complexes of tetraspanins with integrins: more than meets the eye / J Cell Sci 114 : 4143 ~ 51
Burbach BJ / 2007 / T-cell receptor signaling to integrins / Immunol Rev 218 : 65 ~ 81
Cai S / 2005 / CD98 modulates integrin β1 function in polarized epithelial cells / J Cell Sci 18 : 889 ~ 99
Bellone G / 1989 / Identification of a new epitope of the 4F2/44D7 molecular complex present on sarcolemma and isolated cardiac fibers / Eur J Immunol 19 : 1 ~ 8
Berditchevski F / 2001 / Complexes of tetraspanins with integrins: more than meets the eye / J Cell Sci 114 : 4143 ~ 51
Burbach BJ / 2007 / T-cell receptor signaling to integrins / Immunol Rev 218 : 65 ~ 81
Cai S / 2005 / CD98 modulates integrin β1 function in polarized epithelial cells / J Cell Sci 18 : 889 ~ 99
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