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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 78 - 85 (8page)
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CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we studied the expression and function of CD137 in human monocytic THP-1 cells, which we found constitutively expresses CD137 at the mRNA and protein level. Cross-linking of CD137 increased the secretion of IL-8 and TNF-a, promoted the expression of CD54 and CD11b, and increased adhesion to ECM proteins. In particular CD137-induced adhesion of THP-cells was inhibited by an inhibitor of MEK, but not by a p38 kinase inhibitor. Taken together, these results show that the adhesion and cytokine production of THP-1 cells induced by CD137 occurs via activation of MEK, which results in the activation of ERK-1/2 signaling pathways. Therefore, this study suggests that CD137 induces an activating and migrating signal during inflammatory processes.
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참고문헌 (26)
참고문헌 신청
/ / 4-1BBcostimulation promotes human T cell adhesion to fibronectin : 13 ~ 23
/ / Differential regulation of tumornecrosis factor-alpha in human alveolar macrophages andperipheral blood monocytes ge (rd m) : 57 ~ 63
/ / Mechanism of monocyte activation and expression ofproinflammatory cytochemokines by placenta growth factor : 1515 ~ 24
/ / T-cell activation molecule CD137 binds to extracellularmatrix proteins : 10360 ~ 4
/ / The tea flavonoidepigallocatechin-3-gallate reduces cytokine-inducedVCAM-1 expression and monocyte adhesion to endothelialcells : 659 ~ 65
/ / Differential regulation of tumornecrosis factor-alpha in human alveolar macrophages andperipheral blood monocytes ge (rd m) : 57 ~ 63
/ / Mechanism of monocyte activation and expression ofproinflammatory cytochemokines by placenta growth factor : 1515 ~ 24
/ / T-cell activation molecule CD137 binds to extracellularmatrix proteins : 10360 ~ 4
/ / The tea flavonoidepigallocatechin-3-gallate reduces cytokine-inducedVCAM-1 expression and monocyte adhesion to endothelialcells : 659 ~ 65
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