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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 501 - 509 (9page)
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4-1BB, a transmembrane molecule, member of the tumor necrosis factor receptor superfamily, is an important costimulatory molecule in the immune response, plays a key role in the clonal expansion and survival of CD8+ T cels. In this study, we in-vestigated 4-1BB regulation of CD4+ T cell res-ponses using 4-1B transgenic (TG) mice that constitutively expresed 4-1B on mature T cels. We first showed that CD4+ T cels of 4-1B TG mice had more sustained proliferative capacity in response to TCR/4-1BB stimulation in vitro com-exhibited a more elevated contact hypersensitivity (CHS) response mediated by CD4+ Th1 cels due to more vigorous expansion of and apoptotic inhibition of CD4+T cells. Finally, CD4+T cels of 4-1BB TG mice had a heightened capacity for T cell priming. Overall, our results demonstrate the involvement of 4-1BB in CD4+ Th1 cel responses by regulating the clonal expansion and survival of CD4+ T cels as seen in CD8+ T cells.
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