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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 230 - 239 (10page)
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Expresion of matrix metaloproteinase-2 and -9 (MP-2 and MP-9), which corelates with tumor invasion and metastasis, has been known to be ways. Since the CD9 membrane protein has been implicated in signal transduction and malignant progresion of cancer cels, we examined the functional involvement of CD9 in the regulation of MMP-2 and MMP-9 expresion by using stable CD9 transfectant clones of MelJuso human mela-noma cels. The CD9 cDNA-transfected cels with elevated CD9 expression displayed increased MP-2 and decreased MP-9 expression when compared with the mock transfectant cels. Among several signal pathway inhibitors tested, SB203580 and SP600125, which inhibit p38 MAPK CD9-stimulated MP-2 expresion. Phosphoryl-ation levels of p38 MAPK and c-Jun in MelJuso cels were also significantly increased by CD9 transfection. In adition, the down-regulation of p38 MAPK and JNK by siRNA transfection re-sulted in a decrease in MP-2 expression by MelJuso cels. Promoter analysis and gel shift assay showed that the CD9-induced MP-2 ex-presion is mediated by a functional AP-1 site through interactions with AP-1 transcription fac-tors including c-Jun. These results sugest that CD9 induces MMP-2 expression by activating c- ways in human melanoma cells.
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참고문헌 (28)
참고문헌 신청
/ / An absolute role of the PKC-dependentNF-kappaB activation for induction of MMP-9 in hepatocellularcarcinoma cells : 428 ~ 33
/ / CD9expression in solid non-neuroepithelial tumors and infiltrativeastrocytic tumors : 1195 ~ 203
/ / Changing views of the role ofmatrix metalloproteinases in metastasis : 1260 ~ 70
/ / Direct evidence linkingexpression of matrix metalloproteinase 9 to the metastatic phenotype in transformedrat embryo cells : 92 4293 ~ 97
/ / Regulatory roleof tetraspanin CD9 in tumor-endothelial cell i
/ / CD9expression in solid non-neuroepithelial tumors and infiltrativeastrocytic tumors : 1195 ~ 203
/ / Changing views of the role ofmatrix metalloproteinases in metastasis : 1260 ~ 70
/ / Direct evidence linkingexpression of matrix metalloproteinase 9 to the metastatic phenotype in transformedrat embryo cells : 92 4293 ~ 97
/ / Regulatory roleof tetraspanin CD9 in tumor-endothelial cell i
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