지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 519 - 525 (7page)
이용수
초록· 키워드
오류제보하기
Dysferlin is a plasma membrane protein of skeletal muscle whose deficiency causes Miyoshi myopa-thy, limb girdle muscular dystrophy 2B and distal anterior compartment myopathy. Recent studies have reported that dysferlin is implicated in mem-brane repair mechanism and coimmunoprecipita-tes with caveolin 3 in human skeletal muscle. Caveolin 3 is a principal structural protein of cave-olae membrane domains in striated muscle cels gene (CAV3) cause diferent diseases and where caveolin 3 expression is defective, dysferlin locali-zation is abnormal. We describe the alteration of dysferlin expression and localization in skeletal muscle from a patient with raised serum creatine kinase (hyperCKaemia), whose reduction of cave-olin 3 is caused by a CAV3 P28L mutation. More-over, we performed a study on dysferlin interac-tion with caveolin 3 in C2C12 cells. We show the asociation of dysferlin to cellular membrane of dysferlin and caveolin 3 by immunoprecipitation techniques. We also reproduced caveolinopathy conditions in C2C12 cells by a selective p38 MAP kinase inhibition with SB203580, which blocks the expression of caveolin 3. In this model, myoblasts do not fuse into myotubes and we found that dysferlin expression is reduced. These results un-derline the importance of dysferlin-caveolin 3 rela-tionship for skeletal muscle integrity and propose a cellular model to clarify the dysferlin alteration mechanisms in caveolinopathies.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Structural Characterization for N-Terminal Domain of Caveolin-l
Korean journal of biological sciences
2003 .01
-
Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
Experimental and Molecular Medicine
2006 .01
-
Role of caveolin in the regulation of cell cycle by insulin
한국생명과학회 심포지움
2002 .12
-
Exercise type and muscle fiber specific induction of caveolin-1expression for insulin sensitivity of skeletal muscle
Experimental and Molecular Medicine
2007 .01
-
Co-localization and interaction of human organic anion transporter 4 with caveolin-1 in primary cultured human placental trophoblasts
Experimental and Molecular Medicine
2008 .01
-
Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
Experimental and Molecular Medicine
2011 .01
-
Caveolin-1 regulates osteoclast differentiation by suppressing cFms degradation
Experimental and Molecular Medicine
2015 .01
-
고혈당으로 유도된 신장 mesangial cell에서 nobiletin의 matrix accumulation과 TGF-β1-Src-caveolin-1 signaling에 의한 사구체 경화증 억제효과
Journal of Nutrition and Health
2020 .02
-
Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney
Experimental and Molecular Medicine
2005 .01
-
Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts
Experimental and Molecular Medicine
2009 .01
-
Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts
Experimental and Molecular Medicine
2005 .01
-
The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil
Experimental and Molecular Medicine
2016 .01
-
Expression of aquaporin-5 and its regulation in skeletal muscle cells
Experimental and Molecular Medicine
2002 .01
-
PANC-1세포에서 발현된 재조합 MT1-MMP의 효소 활성
생명과학회지
2008 .03
-
Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells
Experimental and Molecular Medicine
2005 .01
-
Regulatory Effects of Exercise and Dietary Intervention in Mitogen Activated Protein Kinase Signaling Pathways in Rats
Nutritional Sciences
2004 .02
-
Gene Expression Profiling on Skeletal Muscle after Exercise Training
한국생명과학회 심포지움
2008 .10
-
Development-specific Phosphorylation of the 63-kDa Protein by the 9-type Protein Kinase C in Chick Embryonic Skeletal Muscle
한국동물학회 학술대회
1996 .01
-
Elevated SR $Ca^{2+}$ Channel Activity in Diabetic Skeletal Muscles
한국생물물리학회 학술발표회
1997 .01
-
Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
Experimental and Molecular Medicine
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0