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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 267 - 277 (11page)
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In vascular smooth muscle cells (VSMCs), inductionof the heme oxygenase-1 (HO-1) confers vascularprotection against cellular proliferation mainly viaits up-regulation of the cyclin-dependent kinaseinhibitor p21WAF1/CIP1 that is involved in negativeregulation of cellular proliferation. In the presentstudy, we investigated whether the phytochemicalcurcumin and its metabolite tetrahydrocurcumincould induce HO-1 expression and growth inhibitionin rat VSMCs and, if so, whether their antiproliferativeeffect could be mediated via HO-1 expression. Atnon-toxic concentrations, curcumin possessingtwo Michael-reaction acceptors induced HO-1 expressionby activating antioxidant response element(ARE) through translocation of the nuclear transcriptionfactor E2-related factor-2 (Nrf2) into thenucleus and also inhibited VSMC growth triggeredby 5% FBS in a dose-dependent manner. In contrast,tetrahydrocurcumin lacking Michael-reaction accep -tor showed no effect on HO-1 expression, AREactivation and VSMC growth inhibition. The antiproliferativeeffect of curcumin in VSMCs was accompaniedby the increased expression of p21WAF1/CIP1.
Inhibition of VSMC growth and expression ofp21WAF1/CIP1by curcumin were partially, but notcompletely, abolished when the cells were coincubatedwith the HO inhibitor tin protoporphyrin.
In human aortic smooth muscle cells (HASMCs),curcumin also inhibited growth triggered by TNF-αand increased p21WAF1/CIP1expression via HO-1-dependent manner. Our findings suggest that curcuminhas an ability to induce HO-1 expression,presumably through Nrf2-dependent ARE activation,in rat VSMCs and HASMCs, and provide evidence thatthe antiproliferative effect of curcumin is considerablylinked to its ability to induce HO-1 expression.
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참고문헌 (26)
참고문헌 신청
Andreadi CK / 2006 / Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, induction of hemeox-ygenase-1 by dietary polyphenols 6
Balogun E / 2003 / Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant- responsive element 371 : 887 ~ 895
Banning A / 2005 / The GI-GPx gene is a target for Nrf2 25 : 4914 ~ 4923
Braun-Dullaeus RC / 1998 / Cell cycle pro-gression: new therapeutic target for vascular proliferative disease 98 : 82 ~ 89
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of cur-cumin a component of tumeric (Curcuma longa). 9 : 161 ~ 168
Balogun E / 2003 / Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant- responsive element 371 : 887 ~ 895
Banning A / 2005 / The GI-GPx gene is a target for Nrf2 25 : 4914 ~ 4923
Braun-Dullaeus RC / 1998 / Cell cycle pro-gression: new therapeutic target for vascular proliferative disease 98 : 82 ~ 89
Chainani-Wu N / 2003 / Safety and anti-inflammatory activity of cur-cumin a component of tumeric (Curcuma longa). 9 : 161 ~ 168
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