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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 765 - 771 (7page)
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초록· 키워드
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Timely cell cycle regulation is conducted by sequential
activation of a family of serine-threonine kinases called
cycle dependent kinases (CDKs). Tight CDK regulation
involves cyclin dependent kinase inhibitors (CKIs)
which ensure the correct timing of CDK activation in
different phases of the cell cycle. One CKI of importance
is p27KIP1. The regulation and cellular localization
of p27KIP1 can result in biologically contradicting
roles when found in the nucleus or cytoplasm
of both normal and tumor cells. The p27KIP1 protein is
mainly regulated by proteasomal degradation and its
downregulation is often correlated with poor prognosis
in several types of human cancers. The protein
can also be functionally inactivated by cytoplasmic localization
or by phosphorylation. The p27KIP1 protein is
an unconventional tumor suppressor because mutation
of its gene is extremely rare in tumors, implying the
normal function of the protein is deranged during tumor
development. While the tumor suppressor function
is mediated by p27KIP1's inhibitory interactions
with the cyclin/CDK complexes, its oncogenic function
is cyclin/CDK independent, and in many cases correlates
with cytoplasmic localization. Here we review the
basic features and novel aspects of the p27KIP1 protein,
which displays genetically separable tumor suppressing
and oncogenic functions.
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참고문헌 (24)
참고문헌 신청
Bagui TK / 2009 / Inhibition of p27Kip1 gene transcription by mitogens / Cell Cycle 8 : 115 ~ 124
Batsi C / 2009 / Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation / Bi
Besson A / 2004 / p27Kip1 modulates cell migration through the regulation of RhoA activation / Genes Dev 18 : 862 ~ 876
Besson A / 2007 / Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype / Genes Dev 21 : 1731 ~ 1746
Besson A / 2008 / CDK inhibitors: Cell cycle regulators and beyond / Dev Cell 14 : 159 ~ 169
Batsi C / 2009 / Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation / Bi
Besson A / 2004 / p27Kip1 modulates cell migration through the regulation of RhoA activation / Genes Dev 18 : 862 ~ 876
Besson A / 2007 / Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype / Genes Dev 21 : 1731 ~ 1746
Besson A / 2008 / CDK inhibitors: Cell cycle regulators and beyond / Dev Cell 14 : 159 ~ 169
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G1 Arrest of U937 Human Monocytic Leukemia Cells by Sodium Butyrate, an HDAC Inhibitor, Via Induction of Cdk Inhibitors and Down-regulation of pRB Phosphorylation
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HY253, a Novel Decahydrofluorene Analog, Induces Apoptosis via Intrinsic Pathway and Cell Cycle Arrest in Liver Cancer HepG2 Cells
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The aspects of protein kinase c isozymes during the induction of apoptosis by protein kinase c inhibitor in PC-3, human prostate cancer cell line
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