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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 186 - 192 (7page)
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초록· 키워드
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Ultraviolet B (UVB) irradiation of skin induces an acute inflammation. Cyclooxygenase-2 (COX-2) protein plays key roles in acute inflammation in UVB-irradiated keratinocyte cell line HaCaT. Recently, curcumin has been regarded as a promising anti-inflammatory agent due to its ability to inhibit COX-2 expression. However, it remains largely unknown whether curcumin inhibits the UVB-induced COX-2 expression in HaCaT cells. This study was undertaken to clarify the effect of curcumin on the expression of COX-2 in UVBirradiatedUVBirradiated HaCaT cells and further determined the molecular mechanisms associated with this process. In this study, we have found that the expression of COX-2 mRNA and protein were up-regulated in UVB-irradiated HaCaT cells in a doseand time-dependent manner. Interestingly, treatment with curcumin strongly inhibited COX-2 mRNA and protein expressions in UVB-irradiated HaCaT cells. Notably, there was effective inhibition by curcumin on UVB-induced activations of p38 MAPK and JNK in HaCaT cells. The DNA binding activity of AP-1 transcription factor was also markedly decreased with curcumin treatment in UVB-irradiated HaCaT cells. These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells. We propose that curcumin may be applied as an effective and novel sunscreen drug for the protection of photoinflammation.
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참고문헌 (29)
참고문헌 신청
/ / c-Jun N-terminal phosphorylation correlates withactivation of the JNK subgroup but not the ERK subgroupof mitogen-activated protein kinases : 6683 ~ 8
/ 1995 / Transcriptional regulation by MAP kinases : 459 ~ 67
/ 1997 / Regulation and function of the JNKsubgroup of MAP kinases : 85 ~ 104
/ 1999 / Redox signaling: hydrogen peroxide as intracellularmessenger : 53 ~ 9
/ 2001 / Molecular mechanisms underlying chemopreventiveactivities of anti-inflammatory phytochemicals down-regulationof COX-2 and iNOS through suppression of NF-kappaB acti
/ 1995 / Transcriptional regulation by MAP kinases : 459 ~ 67
/ 1997 / Regulation and function of the JNKsubgroup of MAP kinases : 85 ~ 104
/ 1999 / Redox signaling: hydrogen peroxide as intracellularmessenger : 53 ~ 9
/ 2001 / Molecular mechanisms underlying chemopreventiveactivities of anti-inflammatory phytochemicals down-regulationof COX-2 and iNOS through suppression of NF-kappaB acti
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