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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 712 - 720 (9page)
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Synthetic oligodeoxynucleotides (ODN) with a CpGmotif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum deprivation through increased expression of FLICE-like inhibitory protein (FLIP). CpG ODN-mediated anti-apoptosis depended on the TLR9-Akt-FoxO3a signaling pathway. Inhibition of TLR9 by small interfering (si) RNA or an inhibitor suppressed CpG ODN-mediated anti-apoptosis. Analysis of signaling pathways revealed that the anti-apoptotic effect of CpG ODN required phosphorylation of FoxO3a and its translocation from the nucleus to the cytosol. Overexpression of FoxO3a increased apoptosis induced by serum deprivation and CpG ODN blocked these effects through FLIP expression. In contrast,siRNA knock-down of FoxO3a decreased apoptosis by serum deprivation. In addition, Akt activation was involved in CpG ODN-induced phosphorylation of FoxO3a, expression of FLIP, and anti-apoptosis. Taken together, these results demonstrate the involvement of Akt-FoxO3a in TLR9-mediated anti-apoptosis and indicate that FoxO3a is a distinct regulator for FLIP expression.
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참고문헌 (23)
참고문헌 신청
Bagchi A / 2007 / MyD88-dependent and MyD88- independent pathways in synergy, priming, and tolerance between TLR agonists / J Immunol 178 : 1164 ~ 1171
Bao S / 2005 / Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells / Am J Physiol Lung Cell Mol Physiol 2
Biggs WH 3rd / 2001 / Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse / Mamm Genome 12 : 416 ~
Boraschi D / 2006 / The interleukin-1 receptor family / Vitam Horm 74 : 229 ~ 254
Burgering BM / 2003 / Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty / J Leukoc Biol 73 : 689 ~ 701
Bao S / 2005 / Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells / Am J Physiol Lung Cell Mol Physiol 2
Biggs WH 3rd / 2001 / Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse / Mamm Genome 12 : 416 ~
Boraschi D / 2006 / The interleukin-1 receptor family / Vitam Horm 74 : 229 ~ 254
Burgering BM / 2003 / Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty / J Leukoc Biol 73 : 689 ~ 701
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