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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 114 - 119 (6page)
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초록· 키워드
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Astaxanthin is one of the major carotenoids used in pigment has a great economical value in pharmaceutical markets, feeding, nutraceutical and food industries. This study was to increase the production of astaxanthin by co-expression with transformed Escherichia coli using six genes involved in the non-mevalonate pathway. Involved in the non-mevalonate biosynthetic pathway of the strain Kocuria gwangalliensis were cloned dxs, ispC, ispD, ispE, ispF, ispG, ispH and idi genes in order to increase astaxanthin production from the transformed E. coli. And co-expression with the genes to compared the amount of astaxanthin production. This engineered E. coli, containing both the non-mevalonate pathway gene and the astaxanthin biosynthesis gene cluster, produced astaxanthin at 1,100 μg/g DCW (dry cell weight), resulting in approximately three times the production of astaxanthin.
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참고문헌 (18)
참고문헌 신청
Kurihara H / 2002 / Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress / Life Sci 70:2509~2520
Miller M / 1976 / Phaffia, a new yeast genus in the Deuteromycotina (Blastomycetes) / Int. J. Syst. Bacteriol. 26:286~291
Bubrick P. / 1991 / Production of astaxanthin from Haematococcus / Bioresour. Technol. 38:237~239
Yokoyama A / 1994 / Production of astaxanthin and 4-ketozeaxanthin by the marine bacterium, Agrobacterium aurantiacum / Biosci. Biotechnol. Biochem. 58:1842~1844
Harker M / 1998 / Paracoccus marcusii sp. nov., an orange Gram-negative coccus / Int. J. Syst. Bacteriol. 48:543~548
Miller M / 1976 / Phaffia, a new yeast genus in the Deuteromycotina (Blastomycetes) / Int. J. Syst. Bacteriol. 26:286~291
Bubrick P. / 1991 / Production of astaxanthin from Haematococcus / Bioresour. Technol. 38:237~239
Yokoyama A / 1994 / Production of astaxanthin and 4-ketozeaxanthin by the marine bacterium, Agrobacterium aurantiacum / Biosci. Biotechnol. Biochem. 58:1842~1844
Harker M / 1998 / Paracoccus marcusii sp. nov., an orange Gram-negative coccus / Int. J. Syst. Bacteriol. 48:543~548
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