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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제3호
- 발행연도
- 2009.1
- 수록면
- 299 - 306 (8page)
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초록· 키워드
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Dissolved oxygen (DO) has a significant effect on the molecular
weight of hyaluronic acid (HA) during the fermentation of
Streptococcus zooepidemicus. Therefore, to further investigate
the effect of DO on the yield and molecular weight of HA,
this study compared the metabolic flux distribution of S.
zooepidemicus under aerobic conditions at various DO levels.
The metabolic flux analysis demonstrated that the HA
synthesis pathway, considered a dependent network, was
little affected by the DO level. In contrast, the fluxes of lactate
and acetate were greatly influenced, and more ATP was
generated concomitant with acetate at a high DO level.
Furthermore, the has gene expression and HA synthase
activity were both repressed under anaerobic conditions, yet
not obviously affected under aerobic conditions at various
DO levels. Therefore, it was concluded that the HA molecular
weight would seem to depend on the concomitant effect of
the generation of ATP and reactive oxygen species. It is
expected that this work will contribute to a better
understanding of the effect of the DO level on the mechanism
of the elongation of HA chains.
목차
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참고문헌 (23)
참고문헌 신청
Armstrong, D. C. / 1997 / Culture conditions affect the molecular weight properties of hyaluronic acid produced by Streptococcus zooepidemicus / Appl. Environ. Microbiol 63 :
Bai, D. M. / 2004 / Strain improvement of Rhizopus oryzae for over-production of L(+)-lactic acid and metabolic flux analysis of mutants / Biochem. Eng. J 18 : 41 ~ 48
Bitter, T. / 1962 / A modified uronic acid carbazole reaction / Anal. Biochem 4 : 330 ~ 333
Bunn, H. F. / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol. Rev 76 : 839 ~ 885
Crater, D. L. / 1995 / Hyaluronic acid synthesis operon (has) expression in group A Streptococci / J. Biol. Chem 270 : 18452 ~ 18458
Bai, D. M. / 2004 / Strain improvement of Rhizopus oryzae for over-production of L(+)-lactic acid and metabolic flux analysis of mutants / Biochem. Eng. J 18 : 41 ~ 48
Bitter, T. / 1962 / A modified uronic acid carbazole reaction / Anal. Biochem 4 : 330 ~ 333
Bunn, H. F. / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol. Rev 76 : 839 ~ 885
Crater, D. L. / 1995 / Hyaluronic acid synthesis operon (has) expression in group A Streptococci / J. Biol. Chem 270 : 18452 ~ 18458
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