지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제4호
- 발행연도
- 2008.1
- 수록면
- 718 - 724 (7page)
이용수
초록· 키워드
오류제보하기
Dissolved oxygen (DO) and shear stress have pronounced
effects on hyaluronic acid (HA) production, yet various
views persist about their effects on the molecular weight of
HA. Accordingly, this study investigated the effects of DO
and shear stress during HA fermentation. The results showed
that both cell growth and HA synthesis were suppressed
under anaerobic conditions, and the HA molecular mass
was only (1.22±0.02)×106 Da. Under aerobic conditions,
although the DO level produced no change in the biomass
or HA yield, a high DO level favored the HA molecular
mass, which reached a maximum value of (2.19±0.05)×
106 Da at 50% DO. Furthermore, a high shear stress
delayed the rate of HA synthesis and decreased the HA
molecular weight, yet had no clear effect on the HA yield.
Therefore, a high DO concentration and mild shear
environment would appear to be essential to enhance the
HA molecular weight.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Armstrong, D. C. / 1997 / Culture conditions affect the molecular weight properties of hyaluronic acid produced by Streptococcus zooepidemicus. Appl. Environ / Microbiol 63 :
Armstrong, D. C. / 1997 / Growth and amino acid requirement of hyaluronic acid producing Streptococcus zooepidemicus. Appl. Microbiol / Biotechnol 47 : 309 ~ 312
Badino, Jr. A. C. / 2000 / Improving kLa determination in fungal fermentation, taking into account electrode response time. J. Chem. Technol / Biotechnol 75 : 469 ~ 474
Baggenstoss, B. A. / 2006 / Baggenstoss, B. A. and P. H. Weigel. 2006. Size exclusion chromatography-multiangle laser light scattering analysis of hyaluronan size distributio
Bandyopadhyay, B. / 1967 / Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation system. Biotechnol / Bioeng 9 : 533 ~ 544
Armstrong, D. C. / 1997 / Growth and amino acid requirement of hyaluronic acid producing Streptococcus zooepidemicus. Appl. Microbiol / Biotechnol 47 : 309 ~ 312
Badino, Jr. A. C. / 2000 / Improving kLa determination in fungal fermentation, taking into account electrode response time. J. Chem. Technol / Biotechnol 75 : 469 ~ 474
Baggenstoss, B. A. / 2006 / Baggenstoss, B. A. and P. H. Weigel. 2006. Size exclusion chromatography-multiangle laser light scattering analysis of hyaluronan size distributio
Bandyopadhyay, B. / 1967 / Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation system. Biotechnol / Bioeng 9 : 533 ~ 544
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