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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제2호
- 발행연도
- 2018.1
- 수록면
- 293 - 297 (5page)
이용수
초록· 키워드
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Controlling the residual glucose concentration is important for improving productivity in L-threonine fermentation. In this study, we developed a procedure to automatically control the feeding quantity of glucose solution as a function of ammonia-water consumption rate. The feeding ratio (RC/N) of glucose and ammonia water was predetermined via a stoichiometric approach, on the basis of glucose-ammonia water consumption rates. In a 5-L fermenter, 102 g/l L-threonine was obtained using our glucose-ammonia water combined feeding strategy, which was then successfully applied in a 500-L fermenter (89 g/l). Therefore, we conclude that an automatic combination feeding strategy is suitable for improving L-threonine production.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Ienczak JL / 2011 / High cell density strategy for poly (3-hydroxybutyrate) production by Cupriavidus necator / Braz. J. Chem. Eng. 28:585~596
SEO, HYUNG-PIL / 2004 / Mass Production of Pullulan with Optimized Concentrations of Carbonand Nitrogen Sources by Aureobasidium pullulans HP-2001 in a 100-LBioreactor with the Inner Pressure / Journal of Microbiology and Biotechnology 14(2):237~242
He X / 2015 / Enhanced L-lysine production from pretreated beet molasses by engineered Escherichia coli in fed-batch fermentation / Bioprocess Biosyst. Eng. 38:1615~1622
Tada K / 2000 / L-Lysine production by exponential feeding of L-threonine / J. Biosci. Bioeng. 90:669~674
Wang J / 2015 / Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli / Biotechnol. Biotechnol. Equip. 29:374~380
SEO, HYUNG-PIL / 2004 / Mass Production of Pullulan with Optimized Concentrations of Carbonand Nitrogen Sources by Aureobasidium pullulans HP-2001 in a 100-LBioreactor with the Inner Pressure / Journal of Microbiology and Biotechnology 14(2):237~242
He X / 2015 / Enhanced L-lysine production from pretreated beet molasses by engineered Escherichia coli in fed-batch fermentation / Bioprocess Biosyst. Eng. 38:1615~1622
Tada K / 2000 / L-Lysine production by exponential feeding of L-threonine / J. Biosci. Bioeng. 90:669~674
Wang J / 2015 / Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli / Biotechnol. Biotechnol. Equip. 29:374~380
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