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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제4호
- 발행연도
- 2018.1
- 수록면
- 561 - 565 (5page)
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초록· 키워드
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The late-stage doxorubicin biosynthesis pathway acting enzyme (DoxA) from Streptomyces peucetius CYP129A2 exhibited substrate promiscuity towards the stilbene group of compounds such as resveratrol. DoxA along with two accessory enzymes ferrdoxin reductase and ferredoxin from spinach hydroxylated resveratrol at the 3’-position in vitro to produce piceatannol. The product was identified by HPLC-PDA and high-resolution HR-qTOF-ESI/ MS analyses in positive mode. The ESI/MS fragments resembled the hydroxylated product of resveratrol.
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참고문헌 (15)
참고문헌 신청
Sirerol JA / 2016 / Role of natural stilbenes in the prevention of cancer / Oxid. Med. Cell Longev. 2016
Lin Y / 2014 / Biotechnological production of plant-specific hydroxylated phenylpropanoids / Biotechnol. Bioeng. 111:1895~1899
Brisdelli F / 2009 / Resveratrol: a natural polyphenol with multiple chemopreventive properties / Curr. Drug Metab. 10:530~546
Potter GA / 2002 / The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 / Br. J. Cancer 86:774~778
Piotrowska H / 2012 / Biological activity of piceatannol: leaving the shadow of resveratrol / Mutat. Res. 750:60~82
Lin Y / 2014 / Biotechnological production of plant-specific hydroxylated phenylpropanoids / Biotechnol. Bioeng. 111:1895~1899
Brisdelli F / 2009 / Resveratrol: a natural polyphenol with multiple chemopreventive properties / Curr. Drug Metab. 10:530~546
Potter GA / 2002 / The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 / Br. J. Cancer 86:774~778
Piotrowska H / 2012 / Biological activity of piceatannol: leaving the shadow of resveratrol / Mutat. Res. 750:60~82
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