지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제4호
- 발행연도
- 2018.1
- 수록면
- 520 - 526 (7page)
이용수
초록· 키워드
오류제보하기
Conessine, a steroidal alkaloid, is a potent histamine H3 antagonist with antimalarial activity. We recently reported that conessine treatment interferes with H2O2-induced cell death by regulating autophagy. However, the cellular signaling pathways involved in conessine treatment are not fully understood. Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1. Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-κB-dependent transcription, and p53-dependent transcription. We also showed by quantitative RT-PCR and western blot assays that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1. Finally, we demonstrated that conessine treatment reduced dexamethasone-induced muscle atrophy using differentiated C2C12 cells. These results collectively suggest that conessine is potentially useful in the treatment of muscle atrophy.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bodine SC / 2014 / Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1 / Am. J. Physiol. Endocrinol. Metab. 307:E469~E484
Attaix D / 2010 / MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis / Curr. Opin. Clin. Nutr. Metab. Care 13:223~224
Fitts RH / 2001 / Functional and structural adaptations of skeletal muscle to microgravity / J. Exp. Biol. 204:3201~3208
Bodine SC / 2001 / Identification of ubiquitin ligases required for skeletal muscle atrophy / Science 294:1704~1708
Clarke BA / 2007 / The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle / Cell Metab. 6:376~385
Attaix D / 2010 / MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis / Curr. Opin. Clin. Nutr. Metab. Care 13:223~224
Fitts RH / 2001 / Functional and structural adaptations of skeletal muscle to microgravity / J. Exp. Biol. 204:3201~3208
Bodine SC / 2001 / Identification of ubiquitin ligases required for skeletal muscle atrophy / Science 294:1704~1708
Clarke BA / 2007 / The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle / Cell Metab. 6:376~385
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
C2C12 근관세포에서 dexamethasone 및 hydrogen peroxide에 의한 근위축 유도
생명과학회지
2017 .12
-
콩잎 추출물의 근위축 개선 효과
생명과학회지
2023 .12
-
마우스 C2C12 근관세포에서 AICAR로 유도된 근위축에 미치는 오미자 추출물의 영향
생명과학회지
2015 .03
-
미역 추출물과 알긴산의 근육손실 억제 효능
생명과학회지
2021 .02
-
C2C12 근관세포에서 상엽에 의한 AMPK의 불활성화와 AICAR로 유도된 근위축 억제의 연관성에 관한 연구
생명과학회지
2018 .04
-
LPS-Induced Modifications in Macrophage Transcript and Secretion Profiles Are Linked to Muscle Wasting and Glucose Intolerance
Journal of Microbiology and Biotechnology
2024 .02
-
Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy in vivo and in vitro
Nutrition Research and Practice
2024 .08
-
Umami taste receptor suppresses cancer cachexia by regulating skeletal muscle atrophy in vivo and in vitro
Nutrition Research and Practice
2024 .08
-
발아 서목태 가수분해물의 근위축 억제 효과
생명과학회지
2023 .03
-
Chrysin의 고농도 포도당에 노출된 C2C12 세포와 제2형 당뇨병 동물모델에서 근육전사인자 조절 및 근육분해 완화를 통한 당뇨병성 근감소증 억제 효과
Journal of Nutrition and Health
2024 .10
-
Gromwell ( Lithospermum erythrorhizon ) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis
Journal of Microbiology and Biotechnology
2024 .03
-
De novo assembly and characterization of transcriptome in the medicinal plant Euphorbia jolkini
Genes & Genomics
2020 .01
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
Inhibitory Effects of Standardized Leonurus japonicus Extract and Its Bioactive Leonurine on TNF-α-Induced Muscle Atrophy in L6 Myotubes
Journal of Microbiology and Biotechnology
2020 .01
-
The effects of scanning position on evaluation of cerebral atrophy level: assessed by item response theory
CSAM(Communications for Statistical Applications and Methods)
2016 .11
-
Evaluation of Muscle Tension in Hemiplegia Patients with a Real-time Monitoring System during High Intensity Laser Therapy
Current Optics and Photonics
2015 .06
-
길경에서 추출한 polygalacin D가 근원세포 분화 및 근위축에 미치는 영향
Journal of Nutrition and Health
2023 .12
-
Butyrate Ameliorates Lipopolysaccharide-induced Myopathy through Inhibition of JNK Pathway and Improvement of Mitochondrial Function in C2C12 Cells
생명과학회지
2021 .05
-
MiT Family Transcriptional Factors in Immune Cell Functions
Molecules and Cells
2021 .01
-
Steamed Ginseng Berry Powder Ameliorates Skeletal Muscle Atrophy via Myogenic Effects
Journal of Microbiology and Biotechnology
2024 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0