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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 342 - 355 (14page)
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The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmiaassociated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loophelix- leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.
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참고문헌 (116)
참고문헌 신청
Aksan, I. / 1998 / Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo / Mol. Cell. Biol 18:6930~6938
Argani, P. / 2016 / TFEB-amplified renal cell carcinomas: an aggressive molecular subset demonstrating variable melanocytic marker expression and morphologic heterogeneity / Am. J. Surg. Pathol 40:1484~1495
Beckmann, H. / 1990 / TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif / Genes Dev 4:167~179
Betschinger, J. / 2013 / Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3 / Cell 153:335~347
Brady, O. A. / 2018 / The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage / Elife 7:e40856
Argani, P. / 2016 / TFEB-amplified renal cell carcinomas: an aggressive molecular subset demonstrating variable melanocytic marker expression and morphologic heterogeneity / Am. J. Surg. Pathol 40:1484~1495
Beckmann, H. / 1990 / TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif / Genes Dev 4:167~179
Betschinger, J. / 2013 / Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3 / Cell 153:335~347
Brady, O. A. / 2018 / The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage / Elife 7:e40856
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