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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제4호
- 발행연도
- 2018.1
- 수록면
- 566 - 570 (5page)
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초록· 키워드
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Because glycosylation of aesculetin and its 6-glucoside, aesculin, enhances their biological activities and physicochemical properties, whole-cell biotransformation and enzymatic synthesis methodologies using Neisseria polysaccharea amylosucrase were compared to determine the optimal production method for glycoside derivatives. High-performance liquid chromatography analysis of reaction products revealed two glycosylated products (AGG1 and AGG2) when aesculin was used as an acceptor, and three products (AG1, AG2, and AG3) when using aesculetin. The whole-cell biotransformation production yields of the major transfer products for each acceptor (AGG1 and AG1) were 85% and 25%, respectively, compared with 68% and 14% for enzymatic synthesis. These results indicate that whole-cell biotransformation is more efficient than enzymatic synthesis for the production of glycoside derivatives.
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참고문헌 (17)
참고문헌 신청
Thuong PT / 2009 / Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla / Biol. Pharm. Bull. 32:1527~1532
Shin E / 2010 / Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells / Biol. Pharm. Bull. 33:1610~1614
Witaicenis A / 2014 / Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives / Phytomedicine 21:240~246
Kaneko T / 2004 / Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamsters by esculetin and esculin / Free Radical Res. 38:839~846
Wang CJ / 2002 / Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin / Cancer Lett. 183:163~168
Shin E / 2010 / Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells / Biol. Pharm. Bull. 33:1610~1614
Witaicenis A / 2014 / Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives / Phytomedicine 21:240~246
Kaneko T / 2004 / Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamsters by esculetin and esculin / Free Radical Res. 38:839~846
Wang CJ / 2002 / Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin / Cancer Lett. 183:163~168
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