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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제2호
- 발행연도
- 2017.1
- 수록면
- 207 - 218 (12page)
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초록· 키워드
오류제보하기
Clustered regulatory interspaced short palindromic repeats (CRISPR) in association with CRISPR-associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make the CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPRCas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects, and optimizing of innovative strategies. In summary, the CRISPR-Cas system could be employed in a number of applications, including providing model systems, rectification of detrimental mutations, and antiviral therapies.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Abudayyeh OO / 2016 / C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector / Science 353 : aaf5573 ~
Chylinski K / 2013 / The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems / RNA Biol 10 : 726 ~ 737
Cong L / 2013 / Multiplex genome engineering using CRISPR/Cas systems / Science 339 : 5 ~
Deltcheva E / 2011 / CRISPR RNA maturation by transencod ed small RNA a nd host factor RNase III / Nature 471 : 602 ~ 607
Doudna JA / 2014 / Genome editing. The new frontier of genome engineering with CRISPR-Cas9 / Science 346 : 1258096 ~
Chylinski K / 2013 / The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems / RNA Biol 10 : 726 ~ 737
Cong L / 2013 / Multiplex genome engineering using CRISPR/Cas systems / Science 339 : 5 ~
Deltcheva E / 2011 / CRISPR RNA maturation by transencod ed small RNA a nd host factor RNase III / Nature 471 : 602 ~ 607
Doudna JA / 2014 / Genome editing. The new frontier of genome engineering with CRISPR-Cas9 / Science 346 : 1258096 ~
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