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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제10호
- 발행연도
- 2017.1
- 수록면
- 1,820 - 1,826 (7page)
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Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is recognized by Toll-like receptor 2, expressed on certain mammalian cell surfaces, initiating signaling cascades that include nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase. There are many structural and functional varieties of LTA, which vary according to the different species of gram-positive bacteria that produce them. In this study, we examined whether LTA isolated from Staphylococcus aureus (aLTA) affects the expression of junction proteins in keratinocytes. In HaCaT cells, tight junctionrelated gene expression was not affected by aLTA, whereas adherens junction-related gene expression was modified. High doses of aLTA induced the phosphorylation of extracellular signal-regulated protein kinases 1 and 2, which in turn induced the epithelial-mesenchymal transition (EMT) of HaCaT cells. When cells were given a low dose of aLTA, however, NF-κB was activated and the total cell population increased. Taken together, our study suggests that LTA from S. aureus infections in the skin may contribute both to the outbreak of EMTmediated carcinogenesis and to the genesis of wound healing in a dose-dependent manner.
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참고문헌 (21)
참고문헌 신청
Alistair JL / 2002 / How bacteria could cause cancer: one step at a time / Trends Microbiol 10 : 293 ~ 299
Anderson JM. / 2001 / Molecular structure of tight junctions and their role in epithelial transport / News Physiol. Sci 16 : 126 ~ 130
Hattar K / 2006 / Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechani
Jeong JH / 2015 / Differential immune-stimulatory effects of LTAs from different lactic acid bacteria via MAPK signaling pathway in RAW 264.7 cells / Immunobiology 220 : 460
Johnson DA / 1999 / 3-O-Desacyl monophosphoryl lipid A derivatives: synthesis and immunostimulant activities / J. Med. Chem 42 : 4640 ~ 4649
Anderson JM. / 2001 / Molecular structure of tight junctions and their role in epithelial transport / News Physiol. Sci 16 : 126 ~ 130
Hattar K / 2006 / Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechani
Jeong JH / 2015 / Differential immune-stimulatory effects of LTAs from different lactic acid bacteria via MAPK signaling pathway in RAW 264.7 cells / Immunobiology 220 : 460
Johnson DA / 1999 / 3-O-Desacyl monophosphoryl lipid A derivatives: synthesis and immunostimulant activities / J. Med. Chem 42 : 4640 ~ 4649
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