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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제11호
- 발행연도
- 2018.1
- 수록면
- 1,937 - 1,945 (9page)
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Malassezia pachydermatis is a commensal yeast found on the skin of dogs. However, M. pachydermatis is also considered an opportunistic pathogen and is associated with various canine skin diseases including otitis externa and atopic dermatitis, which usually require treatment using an azole antifungal drug, such as ketoconazole. In this study, we isolated a ketoconazole-resistant strain of M. pachydermatis, designated “KCTC 27587,” from the external ear canal of a dog with otitis externa and analyzed its resistance mechanism. To understand the mechanism underlying ketoconazole resistance of the clinical isolate M. pachydermatis KCTC 27587, the whole genome of the yeast was sequenced using the PacBio platform and was compared with M. pachydermatis type strain CBS 1879. We found that a ~84-kb region in chromosome 4 of M. pachydermatis KCTC 27587 was tandemly quadruplicated. The quadruplicated region contains 52 protein coding genes, including the homologs of ERG4 and ERG11, whose overexpression is known to be associated with azole resistance. Our data suggest that the quadruplication of the ~84-kb region may be the cause of the ketoconazole resistance in M. pachydermatis KCTC 27587.
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참고문헌 (37)
참고문헌 신청
Hill PB / 2006 / Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice / Vet. Rec 158:533~539
Saridomiche lakis MN / 2007 / Aetiology of canine otitis externa: a retrospective study of 100 cases / Vet. Dermatol 18:341~347
Korbelik J / 2018 / Analysis of the otic mycobiota in dogs with otitis externa compared to healthy individuals / Vet. Dermatol 29:417-e138
Negre A / 2009 / Evidence-based veterinary dermatology: a systematic review of interventions for Malassezia dermatitis in dogs / Vet. Dermatol 20:1~12
I lahi A / 2018 / Molecular epidemiology of a Malassezia pachydermatis neonatal unit outbreak / Med. Mycol 56:69~77
Saridomiche lakis MN / 2007 / Aetiology of canine otitis externa: a retrospective study of 100 cases / Vet. Dermatol 18:341~347
Korbelik J / 2018 / Analysis of the otic mycobiota in dogs with otitis externa compared to healthy individuals / Vet. Dermatol 29:417-e138
Negre A / 2009 / Evidence-based veterinary dermatology: a systematic review of interventions for Malassezia dermatitis in dogs / Vet. Dermatol 20:1~12
I lahi A / 2018 / Molecular epidemiology of a Malassezia pachydermatis neonatal unit outbreak / Med. Mycol 56:69~77
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