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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제10호
- 발행연도
- 2008.1
- 수록면
- 1,683 - 1,688 (6page)
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초록· 키워드
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Lactobacillus casei 3260 (L. casei 3260) was evaluated in relation to the inflammatory response mediated by lipopolysaccharide (LPS)-induced nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in Raw264.7 macrophage cells. The treatment of Raw264.7 cells with L.
casei 3260 significantly inhibited the secretion of tumor necrosis factor-α (TNF-α) and prostaglandins E2 (PGE2), followed by suppression of COX-2. To clarify the molecular mechanism, the inhibitory effect of L. casei 3260 on the NF-κB signaling pathway was examined based on the luciferase reporter activity. Although the treatment of Raw264.7 cells with L. casei 3260 did not affect the transcriptional activity of NF-κB, it did inhibit NF-κB activation, as determined by the cytosolic p65 release and degradation of I-κBα. Therefore, these findings suggest that the suppression of COX-2 through inhibiting the NF-κB activation by LPS may be associated with the antiinflammatory effects of L. casei 3260 on Raw264.7 cells.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Avonts, L. / 2004 / Cell growth and bacteriocin production of probiotic Lactobacillus strains in different media / Dairy 14 : 947 ~ 955
Bai, S. K. / 2005 / β-Carotene inhibits inflammatory gene expression in LPS-stimulated macrophage by suppressing redox-based NF-κB activation. Exp. Mol / Med 37 : 323 ~ 334
Bautista-Garfias, C. R. / 1999 / Enhancement of resistance in mice treated with Lactobacillus casei:Effect on Trichinella spiralis infection.Vet.Parasitol.80:251-260 / Vet. P
Billich, A. / 2005 / Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1 beta and TNF-alpha induced production of infl
Ching, L. S. / 2001 / α-Tocopherol content in 62 edible tropical plants. J. Agric / Food Chem 49 : 3101 ~ 3105
Bai, S. K. / 2005 / β-Carotene inhibits inflammatory gene expression in LPS-stimulated macrophage by suppressing redox-based NF-κB activation. Exp. Mol / Med 37 : 323 ~ 334
Bautista-Garfias, C. R. / 1999 / Enhancement of resistance in mice treated with Lactobacillus casei:Effect on Trichinella spiralis infection.Vet.Parasitol.80:251-260 / Vet. P
Billich, A. / 2005 / Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1 beta and TNF-alpha induced production of infl
Ching, L. S. / 2001 / α-Tocopherol content in 62 edible tropical plants. J. Agric / Food Chem 49 : 3101 ~ 3105
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