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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제3호
- 발행연도
- 2015.1
- 수록면
- 334 - 342 (9page)
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4-O-Methylhonokiol (MH), a bioactive compound derived from Magnolia officinalis, is known to exhibit antitumor effects in various cancer cells. However, the precise mechanism of its anticancer activity in cervical cancer cells has not yet been studied. In this study, we demonstrated that MH induces apoptosis in SiHa cervical cancer cells by enhancing peroxisome proliferator-activated receptor-gamma (PPARγ) activation, followed by inhibition of the PI3K/Akt pathway and intrinsic pathway induction. MH upregulated PPARγ and PTEN expression levels while it decreased p-Akt in the MH-induced apoptotic process, thereby supporting the fact that MH is a PPARγ activator. Additionally, MH decreased the expression of Bcl-2 and Bcl-XL, inducing the intrinsic pathway in MH-treated SiHa cells. Furthermore, MH treatment led to the activation of caspase-3/caspase-9 and proteolytic cleavage of polyADP ribose polymerase. The expression levels of Fas (CD95) and E6/E7 oncogenes were not altered by MH treatment. Taken together, MH activates PPARγ/PTEN expression and induces apoptosis via suppression of the PI3K/Akt pathway and mitochondria-dependent pathways in SiHa cells. These findings suggest that MH has potential for development as a therapeutic agent for human cervical cancer.
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참고문헌 (25)
참고문헌 신청
Amblard F / 2006 / Facile purification of honokiol and its antiviral and cytotoxic properties / J. Med. Chem 49 : 3426 ~ 3427
Arora S / 2012 / Honokiol: a novel natural agent for cancer prevention and therapy / Curr. Mol. Med 12 : 1244 ~ 1252
Bosch FX / 2002 / The causal relation between human papillomavirus and cervical cancer / J. Clin. Pathol 55 : 244 ~ 265
Cantley LC / 2002 / The phosphoinositide 3-kinase pathway / Science 296 : 1655 ~ 1657
Chen L / 2005 / Amplification and functional characterization of MUC1promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive P
Arora S / 2012 / Honokiol: a novel natural agent for cancer prevention and therapy / Curr. Mol. Med 12 : 1244 ~ 1252
Bosch FX / 2002 / The causal relation between human papillomavirus and cervical cancer / J. Clin. Pathol 55 : 244 ~ 265
Cantley LC / 2002 / The phosphoinositide 3-kinase pathway / Science 296 : 1655 ~ 1657
Chen L / 2005 / Amplification and functional characterization of MUC1promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive P
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