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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제4호
- 발행연도
- 2015.1
- 수록면
- 554 - 558 (5page)
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초록· 키워드
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Drug delivery systems (DDSs) incorporating bacterial minicells have been evaluated as a very powerful tool in view of biocompatibility. However, limited studies have been carried out on these systems, mainly using minicells from Salmonella sp. and Escherichia coli. Thus, we generated a new minicell-producing strain from an endotoxin-free Corynebacterium glutamicum by the inactivation of genes related to cell division. The two knockout strains, ΔparA and Δncgl1366, showed distinct abilities to produce minicells. The resulting minicells were purified via sequential antibiotic treatments and centrifugations, which resulted in reproducible yields.
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참고문헌 (15)
참고문헌 신청
Date M / 2006 / Secretion of human epidermal growth factor by Corynebacterium glutamicum / Lett. Appl. Microbiol 42 : 66 ~ 70
Huang SL / 2008 / Liposomes in ultrasonic drug and gene delivery / Adv. Drug Deliv. Rev 60 : 1167 ~ 1176
Jivrajani M / 2013 / A combination approach for rapid and high yielding purification of bacterial minicells / J. Microbiol. Meth 92 : 340 ~ 343
Kim SH / 2009 / Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles / Bba-Biomembranes 1788 : 2150 ~ 2159
Letek M / 2008 / Cell growth and cell division in the rod-shaped actinomycete Corynebacterium glutamicum / Anton. Leeuw. Int. J. G 94 : 99 ~ 109
Huang SL / 2008 / Liposomes in ultrasonic drug and gene delivery / Adv. Drug Deliv. Rev 60 : 1167 ~ 1176
Jivrajani M / 2013 / A combination approach for rapid and high yielding purification of bacterial minicells / J. Microbiol. Meth 92 : 340 ~ 343
Kim SH / 2009 / Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles / Bba-Biomembranes 1788 : 2150 ~ 2159
Letek M / 2008 / Cell growth and cell division in the rod-shaped actinomycete Corynebacterium glutamicum / Anton. Leeuw. Int. J. G 94 : 99 ~ 109
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