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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제8호
- 발행연도
- 2015.1
- 수록면
- 1,275 - 1,280 (6page)
이용수
초록· 키워드
오류제보하기
Previously, we performed de novo RNA sequencing of Scolopendra subspinipes mutilans using high-throughput sequencing technology and identified several antimicrobial peptide candidates. Among them, a cationic antimicrobial peptide, scolopendrasin VII, was selected based on its physicochemical properties, such as length, charge, and isoelectric point. Here, we assessed the anticancer activities of scolopendrasin VII against U937 and Jurkat leukemia cell lines. The results showed that scolopendrasin VII decreased the viability of the leukemia cells in MTS assays. Furthermore, flow cytometric analysis and acridine orange/ethidium bromide staining revealed that scolopendrasin VII induced necrosis in the leukemia cells. Scolopendrasin VII-induced necrosis was mediated by specific interaction with phosphatidylserine, which is enriched in the membrane of cancer cells. Taken together, these data indicated that scolopendrasin VII induced necrotic cell death in leukemia cells, probably through interaction with phosphatidylserine. The results provide a useful anticancer peptide candidate and an efficient strategy for new anticancer peptide development.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Chen YQ / 2010 / A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells / Peptides 31 : 1504 ~ 1510
Chiu D / 1979 / Erythrocyte membrane lipid reorganization during the sickling process / Br. J. Haematol 41 : 223 ~ 234
Du Q / 2014 / Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth
Hoskin DW / 2008 / Studies on anticancer activities of antimicrobial peptides / Biochim. Biophys. Acta 1778 : 357 ~ 375
Hwang PM / 1998 / Structure-function relationships of antimicrobial peptides / Biochem. Cell Biol 76 : 235 ~ 246
Chiu D / 1979 / Erythrocyte membrane lipid reorganization during the sickling process / Br. J. Haematol 41 : 223 ~ 234
Du Q / 2014 / Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth
Hoskin DW / 2008 / Studies on anticancer activities of antimicrobial peptides / Biochim. Biophys. Acta 1778 : 357 ~ 375
Hwang PM / 1998 / Structure-function relationships of antimicrobial peptides / Biochem. Cell Biol 76 : 235 ~ 246
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