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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제12호
- 발행연도
- 2017.1
- 수록면
- 2,129 - 2,140 (12page)
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초록· 키워드
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Silibinin is the major active component of silymarin, extracted from the medicinal plant Silybum marianum. Silibinin has potent antibacterial activity; however, the exact mechanism underlying its activity has not been elucidated. Here, we investigated the novel mechanism of silibinin against Escherichia coli. Time-kill kinetic assay showed that silibinin possess a bactericidal effect at minimal inhibitory concentration (MIC) and higher concentrations (2- and 4-fold MIC). At the membrane, depolarization and increased intracellular Ca2+ levels were observed, considered as characteristics of bacterial apoptosis. Additionally, cells treated with MIC and higher concentrations showed apoptotic features like DNA fragmentation, phosphatidylserine exposure, and caspase-like protein expression. Generally, apoptotic death is closely related with ROS generation; however, silibinin did not induce ROS generation but acted as a scavenger of intracellular ROS. These results indicate that silibinin dosedependently induces bacterial apoptosis-like death, which was affected by ROS depletion, suggesting that silibinin is a potential candidate for controlling bacteria.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] -
Abed I / 2015 / Antibacterial effect of flavonoids extracted from seeds of Silybum marianum against common pathogenic bacteria / World J. Exp. Biosci 3 : 36 ~ 39
Borges A / 2015 / Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents / Curr. Med. Chem 22 : 2590 ~ 2614
Bradford MM. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72
Cheung CW / 2010 / Silibinin - a promising new treatment for cancer / Anticancer Agents Med. Chem 10 : 186 ~ 195
Abed I / 2015 / Antibacterial effect of flavonoids extracted from seeds of Silybum marianum against common pathogenic bacteria / World J. Exp. Biosci 3 : 36 ~ 39
Borges A / 2015 / Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents / Curr. Med. Chem 22 : 2590 ~ 2614
Bradford MM. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72
Cheung CW / 2010 / Silibinin - a promising new treatment for cancer / Anticancer Agents Med. Chem 10 : 186 ~ 195
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