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논문 기본 정보
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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제8호
- 발행연도
- 2009.1
- 수록면
- 803 - 809 (7page)
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Recent evidence has revealed the occurrence of an
apoptotic phenotype in Candida albicans that is inducible
with environmental stresses such as acetic acid, hydrogen
peroxide, and amphotericin B. In the present study, we
found that the Chinese herbal medicine Baicalein (BE),
which was one of the skullcapflavones, can induce apoptosis
in C. albicans. The apoptotic effects of BE were detected
by flow cytometry using Annexin V-FITC and DAPI, and
it was confirmed by transmission electron microscopy
analysis. After exposure to 4 μg/ml BE for 12 h, about
10% of C. albicans cells were apoptotic. Both the increasing
intracellular levels of reactive oxygen species (ROS) and
upregulation of some redox-related genes (CAP1, SOD2,
TRR1) were observed. Furthermore, we compared the
survivals of CAP1 deleted, wild-type, and overexpressed
strains and found that Cap1p attenuated BE-initiated cell
death, which was coherent with a higher mRNA level of
the CAP1 gene. In addition, the mitochondrial membrane
potential of C. albicans cells changed significantly ( p<0.001)
upon BE treatment compared with control. Taken together,
our results indicated that BE treatment induced apoptosis
in C. albicans cells, and the apoptosis was associated with
the breakdown of mitochondrial membrane potential.
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참고문헌 (24)
참고문헌 신청
Alarco, A. M. / 1999 / The b-Zip transcription factor Cap1p is involved in multiple resistance and oxidative stress response in Candida albicans / J. Bacteriol 181 : 700 ~ 70
Almeida, T. / 2008 / Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis / Mol. Biol. Cell 19 :
Baek, Y. U. / 2004 / Disruption of γ-glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicans. FEBS Lett. 556: 47-52 / FEBS L
Braun, R. J. / 2006 / Crucial mitochondrial impairment upon CDC48 mutation apoptotic yeast / J. Biol. Chem 281 : 25757 ~ 25767
Cao, Y. Y. / 2008 / In vitro activity of baicalein against Candida albicans biofilms / Int. J. Antimicrob. Agents 32 : 73 ~ 77
Almeida, T. / 2008 / Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis / Mol. Biol. Cell 19 :
Baek, Y. U. / 2004 / Disruption of γ-glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicans. FEBS Lett. 556: 47-52 / FEBS L
Braun, R. J. / 2006 / Crucial mitochondrial impairment upon CDC48 mutation apoptotic yeast / J. Biol. Chem 281 : 25757 ~ 25767
Cao, Y. Y. / 2008 / In vitro activity of baicalein against Candida albicans biofilms / Int. J. Antimicrob. Agents 32 : 73 ~ 77
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