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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제2호
- 발행연도
- 2015.1
- 수록면
- 296 - 301 (6page)
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Chronic kidney diseases are based on uncontrolled immunological and inflammatory responses to pathophysiological renal circumstances such as glomerulonephritis, which is caused by immunological mechanisms of glomerular inflammation with increased production of renal pro-inflammatory cytokines. Pentoxifylline (PTX) exhibits anti-inflammatory properties by inhibiting cytokine and chemokine production through aggregation of erythrocytes and thrombocytes. We synthesized a series of 1,7-substituted methylxanthine derivatives by the Traube purine reaction, and the formation of purine ring was completed through nitrosation, a reduction of the nitroso to the amine by catalytic hydrogenation as derivatives of PTX. Then we studied biological activities such as renal anti-inflammatory effects of the synthesized compounds in the production of cytokines such as nitric oxide (NO), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) and of chemokines such as monocyte chemoattractant protein-1 and IL-8 in Raw 264.7 and HK-2 cells. Renal antiinflammatory activities of this novel series of N-1 and N-7-substituted methylxanthine showed that the N-7 methyl-group-substituted analogs (S7b) showed selective 61% and 77% inhibition of the production of NO and IL-8. The other replacement of the N-1-(CH2)4COCH3 group, as in the case of compound S6c, also showed an effective 50% and 77% inhibition of TNF-α and IL-8 production in LPS-stimulated Raw 264.7 and HK-2 cells.
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참고문헌 (20)
참고문헌 신청
Bacher A / 2005 / Pentoxifylline attenuates the increase in whole blood viscosity after transfusion / Acta Anaesthesiol. Scand 49 : 41 ~ 46
Berk B / 2005 / New 8-substituted xanthine derivatives as potent bronchodilators / Farmaco 60 : 974 ~ 980
Bhat VB / 2001 / Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline / Biochem. Biophys. Res. Commun 288 : 121
Bohm L / 2000 / Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation dam
Cakmak S K / 2012 / Pentoxifylline use in dermatology / Inflamm. Allergy Drug Targets 11 : 422 ~ 432
Berk B / 2005 / New 8-substituted xanthine derivatives as potent bronchodilators / Farmaco 60 : 974 ~ 980
Bhat VB / 2001 / Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline / Biochem. Biophys. Res. Commun 288 : 121
Bohm L / 2000 / Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation dam
Cakmak S K / 2012 / Pentoxifylline use in dermatology / Inflamm. Allergy Drug Targets 11 : 422 ~ 432
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