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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 820 - 826 (7page)
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This study evaluated the anti-inflammatory potential of a grasshopper ketone (GK) isolated from the brown alga Sargassum fulvellum on lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line. GK was isolated and purified from the n-hexane fraction and its structure was verified on the basis of NMR spectroscopic data. GK up to 100 μg/ml is not cytotoxic to RAW 264.7, and is an effective inhibitor of LPS-induced NO production in RAW 264.7 cells. The production of pro-inflammatory cytokines, including IL-6, IL-1β, and TNF-α was found significantly reduced in 0.1-100 μg/ml dose ranges of GK treatment (p < 0.05). We confirmed the dose-dependent and significant inhibition of iNOS and COX-2 proteins expression. In addition, it has been shown that GK induces anti-inflammatory effects by inhibiting MAPKs (ERK, JNK, and p38) and NF-κB p65 phosphorylation. Our results show that the anti-inflammatory properties of GK may be due to the inhibition of the NF-κB and MAPKs pathways, which are associated with the attenuation of cytokine secretion.
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참고문헌 (24)
참고문헌 신청
김보운 / 2014 / LPS로 유도된 RAW 264.7 대식세포에 대한 애기외톨개 모자반(Myagropsis yendoi) 에틸아세테이트 분획물의 항염증 효과 / 한국수산과학회지 47(5):527~536
Lawrence T / 2002 / Antiinflammatory lipid mediators and insights into the resolution of inflammation / Nat. Rev. Immunol 2:787~795
Ljung T / 2006 / Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus non-responders / World J. Gastroenterol 12:3386~3392
곽충실 / 2005 / 한국산 5종 해조류의 항산화효과와 총 폴리페놀 함량과의 관련성 / 한국식품영양과학회지 34(8):1143~1150
김수현 / 2007 / Antioxidant Activity of Sulfated Polysaccharides Isolated from Sargassum fulvellum / Preventive Nutrition and Food Science 12(2):65~73
Lawrence T / 2002 / Antiinflammatory lipid mediators and insights into the resolution of inflammation / Nat. Rev. Immunol 2:787~795
Ljung T / 2006 / Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus non-responders / World J. Gastroenterol 12:3386~3392
곽충실 / 2005 / 한국산 5종 해조류의 항산화효과와 총 폴리페놀 함량과의 관련성 / 한국식품영양과학회지 34(8):1143~1150
김수현 / 2007 / Antioxidant Activity of Sulfated Polysaccharides Isolated from Sargassum fulvellum / Preventive Nutrition and Food Science 12(2):65~73
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