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Objectives: This study aimed to optimize the thread depth and pitch of a recently designed dental implant to provide uniform stress distribution bymeans of a response surface optimization method available in finite element (FE) software. The sensitivity of simulation to different mechanical parameterswas also evaluated. Materials and Methods: A three-dimensional model of a tapered dental implant with micro-threads in the upper area and V-shaped threads in therest of the body was modeled and analyzed using finite element analysis (FEA). An axial load of 100 N was applied to the top of the implants. Themodel was optimized for thread depth and pitch to determine the optimal stress distribution. In this analysis, micro-threads had 0.25 to 0.3 mm depthand 0.27 to 0.33 mm pitch, and V-shaped threads had 0.405 to 0.495 mm depth and 0.66 to 0.8 mm pitch. Results: The optimized depth and pitch were 0.307 and 0.286 mm for micro-threads and 0.405 and 0.808 mm for V-shaped threads, respectively. Inthis design, the most effective parameters on stress distribution were the depth and pitch of the micro-threads based on sensitivity analysis results. Conclusion: Based on the results of this study, the optimal implant design has micro-threads with 0.307 and 0.286 mm depth and pitch, respectively,in the upper area and V-shaped threads with 0.405 and 0.808 mm depth and pitch in the rest of the body. These results indicate that micro-thread parametershave a greater effect on stress and strain values.

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