지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 110 - 115 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveThe objective of this study was to assess the effect of folic acid and multivitamin use during pregnancy on the risk of developing of hypertensive disorder of pregnancy.
MethodsTwo reviewers independently determined all prospective cohort study, retrospective cohort study, large population based cohort study, retrospective secondary analysis, and double blinded, placebo-controlled, randomized clinical trial published using PubMed Medline database, KERIS (Korea Education and Research Information Service), Scopus, and the Cochrane Central Register of controlled trials comparing before conception throughout pregnancy intake oral multivitamin containing folic acid or folic acid alone. Meta-analyses were estimated with odds ratios and 95% confidence intervals (CIs) using random effect analysis according to heterogeneity of studies.
ResultsData from six effect sizes from six studies involving 201,661 patients were enrolled. These meta-analyses showed multivitamin containing folic acid or folic acid alone was not significantly effective in reducing gestational hypertension or preeclampsia incidence (odds ratio, 0.91; 95% CI, 0.81 to 1.03) than the placebo. And the difference of effective sizes of preeclampsia and gestational hypertension according to two dependent variables, multivitamin and folic acid were not significant, respectively (point estimate, 0.66; 95% CI, 0.46 to 0.96).
ConclusionThese meta-analyses demonstrate multivitamin containing folic acid or folic acid alone was not significantly effective in reducing gestational hypertension or preeclampsia incidence.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Leeman L / 2008 / Hypertensive disorders of pregnan-cy / Am Fam Physician 78:93~100
Cifkova R. / 2011 / Why is the treatment of hypertension in pregnancy still so difficult? / Expert Rev Cardiovasc Ther 9:647~649
Sibai BM / 2003 / Diagnosis and management of gestational hypertension and preeclampsia / Obstet Gynecol 102:181~192
2000 / Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy / Am J Obstet Gynecol 183:S1~S22
Yanez P / 2013 / Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude / Arch Gynecol Obstet 288:1011~1015
Cifkova R. / 2011 / Why is the treatment of hypertension in pregnancy still so difficult? / Expert Rev Cardiovasc Ther 9:647~649
Sibai BM / 2003 / Diagnosis and management of gestational hypertension and preeclampsia / Obstet Gynecol 102:181~192
2000 / Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy / Am J Obstet Gynecol 183:S1~S22
Yanez P / 2013 / Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude / Arch Gynecol Obstet 288:1011~1015
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