지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 265 - 271 (7page)
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초록· 키워드
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Purpose: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is the first choice of treatment forage-related macular degeneration. However, quite a few eyes treated using conventional dose anti-VEGF(CDAV) have persistent pigment epithelial detachment (PED) on optical coherence tomography. This studyinvestigated the efficacy and safety of high dose anti-VEGF (HDAV) for refractory PED.
Methods: In this retrospective study, 31 eyes of neovascular age-related macular degeneration patients withpersistent PED findings despite six or more intravitreal injections of CDAV (bevacizumab 1.25 mg or ranibizumab2.5 mg) were analyzed. Changes in visual outcome, central foveal thickness, and PED height werecompared before and after HDAV (bevacizumab 5.0 mg) for these refractory PED cases.
Results: The mean age of patients was 67.7 years. The number of CDAV injections was 12.1. The number ofHDAV injections was 3.39. Best-corrected visual acuity in logarithm of the minimum angle of resolution beforeand after HDAV was 0.49 and 0.41 (p < 0.001), respectively. Central foveal thickness before and afterHDAV was 330.06 and 311.10 μm (p = 0.125), respectively. PED height before and after HDAV was 230.28 and204.07 μm (p = 0.014), respectively. There were no serious adverse reactions in all the eyes.
Conclusions: Increasing the dose of bevacizumab in refractory PED may be a possible treatment option.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Klein R / 2004 / The epidemiology of age-related macular degeneration / Am J Ophthalmol 137:486~495
Bressler NM / 2003 / Potential public health impact of Age-Related Eye Disease Study results:AREDS report no. 11 / Arch Ophthalmol 121:1621~1624
Ferris FL 3rd / 1984 / Age-related macular degeneration and blindness due to neovascular maculopathy / Arch Ophthalmol 102:1640~1642
Amin R / 1994 / Growth factor localization in choroidal neovascular membranes of age-related macular degeneration / Invest Ophthalmol Vis Sci 35:3178~3188
Kliffen M / 1997 / Increased expression of angiogenic growth factors in age-related maculopathy / Br J Ophthalmol 81:154~162
Bressler NM / 2003 / Potential public health impact of Age-Related Eye Disease Study results:AREDS report no. 11 / Arch Ophthalmol 121:1621~1624
Ferris FL 3rd / 1984 / Age-related macular degeneration and blindness due to neovascular maculopathy / Arch Ophthalmol 102:1640~1642
Amin R / 1994 / Growth factor localization in choroidal neovascular membranes of age-related macular degeneration / Invest Ophthalmol Vis Sci 35:3178~3188
Kliffen M / 1997 / Increased expression of angiogenic growth factors in age-related maculopathy / Br J Ophthalmol 81:154~162
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